Evidence map›Paper›PMID 40901684›Full record

ArticleWorld journal of gastroenterology2025

Wei Ding, Xin-Qi Xu, Ling-Lin Wu, Qun Wang, Yi-Qin Wang, Wei-Wei Chen, Yu-Lin Tan, Yi-Bo Wang, Hua-Ji Jiang, Jun Dong and 2 more

Abstract read
In one paragraph

Article in World journal of gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Wei DingDepartment of General Surgery, Wujin Hospital Affiliated with Jiangsu University, Changzhou 213162, Jiangsu Province, China.
Xin-Qi XuDepartment of General Surgery, Wujin Hospital Affiliated with Jiangsu University, Changzhou 213162, Jiangsu Province, China.
Ling-Lin WuDepartment of Obstetrics and Gynecology, Wujin Hospital Affiliated with Jiangsu University, Changzhou 213162, Jiangsu Province, China.
Qun WangDepartment of General Surgery, Wujin Hospital Affiliated with Jiangsu University, Changzhou 213162, Jiangsu Province, China.
Yi-Qin WangDepartment of General Surgery, Wujin Hospital Affiliated with Jiangsu University, Changzhou 213162, Jiangsu Province, China.
Wei-Wei ChenDepartment of General Surgery, Wujin Hospital Affiliated with Jiangsu University, Changzhou 213162, Jiangsu Province, China.
Yu-Lin TanDepartment of General Surgery, Wujin Hospital Affiliated with Jiangsu University, Changzhou 213162, Jiangsu Province, China.
Yi-Bo WangDepartment of General Surgery, Wujin Hospital Affiliated with Jiangsu University, Changzhou 213162, Jiangsu Province, China.
Hua-Ji JiangDepartment of General Surgery, Wujin Hospital Affiliated with Jiangsu University, Changzhou 213162, Jiangsu Province, China.
Jun DongDepartment of General Surgery, Wujin Hospital Affiliated with Jiangsu University, Changzhou 213162, Jiangsu Province, China.
Yong-Min YanDepartment of Laboratory, Wujin Hospital Affiliated with Jiangsu University, Changzhou 213162, Jiangsu Province, China.
Xue-Zhong XuDepartment of General Surgery, Wujin Hospital Affiliated with Jiangsu University, Changzhou 213162, Jiangsu Province, China. xxzdoctor@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe progression of non-alcoholic fatty liver disease (NAFLD) to non-alcoholic steatohepatitis (NASH) and liver fibrosis remains poorly understood, though liver sinusoidal endothelial cells (LSECs) are thought to play a central role in disease pathogenesis.

aimTo investigate the role of

methodsWe analysed single-cell transcriptomic data (GSE129516) from NASH and normal mouse models and identified

resultsSingle-cell analysis revealed that

conclusionOur findings indicate a pivotal role of

Indexed as

Endothelial CellsLiverLiver CirrhosisMacrophagesNon-alcoholic Fatty Liver DiseaseAnimalsCell CommunicationCells, CulturedCytokine TWEAKDisease Models, AnimalDisease ProgressionHumansMaleMiceMice, Inbred C57BLSignal TransductionCytokine TWEAKLiver sinusoidal endothelial cellsMacrophage polarizationNon-alcoholic fatty liver diseaseTSC22D1Tumor necrosis factor-like weak inducer of apoptosis

Identifiers

PMID40901684
PMCPMC12400240

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.