ReviewFrontiers in neurology2025
Tectorial membrane: structure, function, and its implications for hearing loss.
Review in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The tectorial membrane (TM) is an essential extracellular matrix in the cochlea, integral to auditory processing by facilitating hair cell stimulation and sound transmission. Despite its vital role, the mechanisms underlying TM-related hearing loss remain unclear. This review aim to discuss the structure and functions of the TM, exploring its role in cochlear mechanics and auditory signal amplification. Abnormalities in TM composition, including disruptions in collagen, glycosaminoglycans, and non-collagenous proteins, are implicated in various forms of hearing loss, including those associated with genetic mutations and ototoxic drug exposure. We also examine the contributions of genes such as
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