Evidence map›Paper›PMID 40901603›Full record

ArticleWorld journal of hepatology2025

Patient factors in responders and non-responders treated with steroids for acute alcohol-associated hepatitis.

Kent W Sabatose, Alexandra Baker, Kevin Kugler, Jude Delikat, Bethany Jowers, Ambuj Kumar, Sadaf Aslam, Jacentha Buggs, Christine Machado-Denis, Nyingi Kemmer and 2 more

Abstract read
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In one paragraph

Article in World journal of hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kent W SabatoseLake Erie College of Osteopathic Medicine, Lakewood Ranch, FL 34211, United States.
Alexandra BakerUniversity of Tampa, Tampa, FL 33606, United States.
Kevin KuglerUniversity of Tampa, Tampa, FL 33606, United States.
Jude DelikatUniversity of South Florida, Tampa, FL 33620, United States.
Bethany JowersUniversity of South Florida, Tampa, FL 33620, United States.
Ambuj KumarResearch Methodology and Biostatistics Core, University of South Florida, Tampa, FL 33612, United States.
Sadaf AslamDepartment of Infectious Disease, University of South Florida, Tampa, FL 33606, United States.
Jacentha BuggsRecovery Surgeon and Associate Medical Director LifeLink of Florida, University of South Florida, Tampa General Medical Group, Tampa, FL 33606, United States.
Christine Machado-DenisDepartment of Psychology, Clinical Psychology, University of South Florida, Tampa General Medical Group, Tampa, FL 33606, United States.
Nyingi KemmerDepartment of Transplant Hepatology, University of South Florida, Tampa General Medical Group, Tampa, FL 33606, United States.
Kiran DhanireddyDepartment of Hepatobiliary and Pancreatic Surgery, Liver Transplant Surgery, University of South Florida, Tampa, FL 33606, United States.
Rashid SyedDepartment of Transplant Hepatology, University of South Florida, Tampa General Medical Group, Tampa, FL 33606, United States. rashid.syed@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSteroids remain the primary treatment for severe alcohol-associated hepatitis (AAH), though there is little available tools to predict patient response to steroids. It was hypothesized that phosphatidylethanol (PEth) value will inversely correlate with response to steroid therapy based on Lille score in AAH.

aimTo assess the relationship of patient factors, focusing on pre-steroid therapy PEth value, to steroid therapy response in AAH.

methodsA retrospective case control study was performed on patients who received ≥ 4 days of steroid therapy for AAH at our hospital between July 1, 2019 and June 30, 2022. A total of 2087 patients were screened for AAH and those treated with steroids were included for statistical analysis utilizing independent sample

resultsNo correlation was found between PEth value, pre-steroids abstinence length, or number of drinks per week pre-steroids and response to steroids. Non-responder status significantly correlated with older age (

conclusionIdentifying non-responders through these identified factors should prompt early referral for liver transplantation. Future prospective studies with larger population size are needed to assess the efficacy of combined pre-steroid age, albumin, bilirubin and other biochemical markers as predictors of steroid response.

Indexed as

Acute alcohol-associated hepatitisPhosphatidylethanolSteroid responseSteroidsTransplant

Identifiers

PMID40901603
PMCPMC12400396

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.