Neutrophil-Inspired Film for Nonadhesive Capture of Tumor Cells through Synergistic Functionalization of Zwitterions and Aptamers.

Yangyang Li, Riyue Shu, Dan Lu, Cheng Zeng, Feng Qi, Shengfu Chen, Lin Zhang, Zhe Tang

Abstract read

In one paragraph

Article in Chem & bio engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yangyang LiZhejiang Key Laboratory of Smart Biomaterials, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310058, China.

Riyue ShuZhejiang Key Laboratory of Smart Biomaterials, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310058, China.

Dan LuZhejiang Key Laboratory of Smart Biomaterials, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310058, China.

Cheng ZengDepartment of Surgery, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu 322000, China.

Feng QiZhejiang Key Laboratory of Smart Biomaterials, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310058, China.

Shengfu ChenZhejiang Key Laboratory of Smart Biomaterials, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310058, China.ORCID https://orcid.org/0000-0002-8153-608X

Lin ZhangZhejiang Key Laboratory of Smart Biomaterials, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310058, China.ORCID https://orcid.org/0000-0002-1337-2538

Zhe TangDepartment of Surgery, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu 322000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of biomaterials capable of capturing nondestructively capturing tumor cells is critical for advancing cancer diagnostics and personalized therapies. However, designing specific capture materials for maintaining the structure of captured cells is still a challenge due to the undesirable nonspecific adhesion. Recent evidence showed that neutrophils possess the tumor cell targeting property via the binding of β-integrin on neutrophil membranes to VCAM-1 expressed on tumor cells and natural antiadhesion properties due to the phosphorylcholine on the cell membrane. Herein, we present a neutrophil-inspired nanofibrous film for the nondestructive capture of tumor cells. The polyurethane and polyacrylonitrile (PU-PAN) blend film was fabricated by electrospinning as a matrix. A tailored zwitterionic polymer of poly-(sulfobetaine methacrylate-

Indexed as

antiadhesionaptamerneutrophil-inspirednondestructive capturetumor cellszwitterionic polymer

Identifiers

PMID40901575

DOI10.1021/cbe.4c00189

PMCPMC12400120

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.