Evidence map›Paper›PMID 40901517›Full record

ArticleFrontiers in medicine2025

Associations between folate metabolism biomarkers and cognitive impairment in older Chinese adults: a cross-sectional study.

Huimin Lv, Jia Li, Lu Chen, Keyi Lu, Xudong Zhao, Mengyuan Guo, Hailong Lu

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PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Huimin Lv *Department of Geriatrics, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.
Jia Li *Department of Geriatrics, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.
Lu Chen *Department of Geriatrics, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.
Keyi LuDepartment of Geriatrics, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.
Xudong ZhaoDepartment of General Medicine, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.
Mengyuan GuoDepartment of Geriatrics, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.
Hailong LuDepartment of Geriatrics, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The role of folate metabolism-related biomarker profiles in age-related cognitive impairment (ARCI) remains unclear. This cross-sectional study aimed to examine the association between folate metabolism-related biomarkers and cognitive performance in older Chinese adults. Methods: We conducted a cross-sectional analysis of 100 participants aged between 56 and 87 years. Cognitive status was classified as ARCI if participants met the cutoff criteria on both the MMSE (<27) and MoCA (<26). Those meeting the cutoff criteria on both MMSE (≥27) and MoCA (≥26) were classified as cognitively normal (CN). Serum levels of folate metabolism-related biomarkers were compared between groups and analyzed for their associations with cognitive scores. Logistic regression was used to examine associations between individual biomarkers and cognitive impairment status. Multiple linear regression analyses were conducted to assess relationships with MMSE and MoCA scores, adjusting for age and education. Results: Cognitive impairment was prevalent among older adults at a rate of 56.3% ( Conclusions: VB2, SAM and Hcy may be associated with cognitive impairment in older Chinese adults and warrant further investigation as potential biomarkers.

Indexed as

age-related cognitive impairmentcross-sectional studyfolate metabolismhomocysteineS-adenosylmethioninevitamin B2

Identifiers

PMID40901517
PMCPMC12399532

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