Evidence map›Paper›PMID 40901455›Full record

ReviewRSC advances2025

Antibacterial activity and mechanistic insights of gallium-based nanoparticles: an emerging frontier in metal-based antimicrobials.

Ikhazuagbe Hilary Ikhazuagbe, Emmanuella Amara Ofoka, Odunola Latifah Odofin, Oshoma Erumiseli, Onuh Emmanuel Edoka, Kelechi Purity Ezennubia, Precious Munachimso Ogbunike, Emmanuel Annan, Somtochukwu Samuel Okonkwo, Joshua Chinazo Dike

Abstract readReview
In one paragraph

Review in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ikhazuagbe Hilary IkhazuagbeDepartment of Research Outreach, Rubber Research Institute of Nigeria Benin City Edo State Nigeria larylans4u@yahoo.com.ORCID https://orcid.org/0000-0003-4165-5639
Emmanuella Amara OfokaWestern Kentucky University, 1906 College Heights Blvd Bowling Green KY 42101 USA.
Odunola Latifah OdofinDepartment of Chemical Engineering, University of North Dakato Grand Forks North Dakato USA.
Oshoma ErumiseliDepartment of Chemistry, Oregon State University 97330 USA.
Onuh Emmanuel EdokaCo-founder Fedox Pharmacy Louisiana 2 Complex Lokogoma Abuja Nigeria.
Kelechi Purity EzennubiaDepartment of Chemistry and Biochemistry, Baylor University 1311 S 5th St Waco Tx. 76706 Texas USA.
Precious Munachimso OgbunikePlant Science and Biotechnology, University of Nsukka Poster Code (410001) Enugu State Nigeria.
Emmanuel AnnanInstitute of Environmental and Human Health, Department of Environmental Toxicology, Texas Tech University Lubbock Texas USA.
Somtochukwu Samuel OkonkwoDepartment of Chemical and Biomolecular Engineering, University of Houston 4800 Calhoun Road Houston TX 77004 USA.
Joshua Chinazo DikeUniversity of Technology Owerri, P.M.B 1526 Owerri Imo State Nigeria.ORCID https://orcid.org/0009-0006-4966-0722

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The global rise of antimicrobial resistance has intensified the search for novel therapeutic agents that act through non-conventional mechanisms. Gallium-based nanoparticles (GaNPs) represent a promising yet underexplored class of metal-based antimicrobials. Owing to their unique ability to mimic iron(iii), GaNPs disrupt key bacterial metabolic processes, particularly those dependent on iron acquisition and utilization. This mini-review provides an overview of recent advances in the development and application of GaNPs for antibacterial therapy. Emphasis is placed on their mechanisms of action, spectrum of activity, and potential biomedical applications. The review also discusses emerging insights into bacterial responses to gallium, including resistance dynamics and synergy with existing antibiotics. As an innovative approach to combat multidrug-resistant pathogens, GaNPs offer a compelling alternative to traditional antimicrobials.

Identifiers

PMID40901455
PMCPMC12400149

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.