ArticleInternational journal of general medicine2025
Evaluation of Diagnostic Efficacy of Targeted Next-Generation Sequencing on Nasopharyngeal Swabs in Pediatric Community-Acquired Pneumonia.
Article in International journal of general medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: The objective of this study is to evaluate diagnostic efficacy of targeted next-generation sequencing (tNGS) on nasopharyngeal (NP) swabs in pediatric community-acquired pneumonia (CAP). Methods: We conducted a retrospective analysis, compiling nasal and bronchoalveolar lavage fluid (BALF) specimens from a cohort of 147 children diagnosed with CAP at Tongling Maternal and Child Health Hospital from May 2023 to October 2024. The diagnostic accuracy of nasal tNGS was evaluated and compared against BALF tNGS and conventional microbiological tests (CMT), which included microbial culture and targeted polymerase chain reaction assays. Results: Nasal tNGS detected a broader range of 25 pathogens, while CMT identified 17, and BALF tNGS identified 21, with significant differences in detection rates favoring tNGS methods (P<0.001). Single pathogen detection rates were 35.6% for nasal tNGS and 54.4% for BALF tNGS, with Conclusion: NP swab-based tNGS technique offers valuable insights for the early etiological diagnosis and treatment of pneumonia, particularly in identifying viral pneumonia.
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