Evidence map›Paper›PMID 40901346›Full record

ArticleWorld journal of radiology2025

Applications of photon-counting CT in oncologic imaging: A systematic review.

Arosh S Perera Molligoda Arachchige, Anna Dashiell, Anton Shiraan Jesuraj, Antonia Immacolata D'Urso, Benedetta Fiore, Martina Cattaneo, Emilia Pierzynska, Sandra Szydelko, Francesca Romana Centini, Yash Verma

Abstract read
In one paragraph

Article in World journal of radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Arosh S Perera Molligoda ArachchigeEmergency Service, GHOL-Hopital de Nyon, Nyon 1260, Vaud, Switzerland. aroshperera@outlook.it.
Anna DashiellFaculty of Medicine, Humanitas University, Pieve Emanuele 20072, Lombardy, Italy.
Anton Shiraan JesurajFaculty of Medicine, Humanitas University, Pieve Emanuele 20072, Lombardy, Italy.
Antonia Immacolata D'UrsoFaculty of Medicine, Humanitas University, Pieve Emanuele 20072, Lombardy, Italy.
Benedetta FioreFaculty of Medicine, Humanitas University, Pieve Emanuele 20072, Lombardy, Italy.
Martina CattaneoFaculty of Medicine, Humanitas University, Pieve Emanuele 20072, Lombardy, Italy.
Emilia PierzynskaFaculty of Medicine, Humanitas University, Pieve Emanuele 20072, Lombardy, Italy.
Sandra SzydelkoFaculty of Medicine, Humanitas University, Pieve Emanuele 20072, Lombardy, Italy.
Francesca Romana CentiniFaculty of Medicine, Humanitas University, Pieve Emanuele 20072, Lombardy, Italy.
Yash VermaDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPhoton-counting detector (PCD) CT represents a transformative advancement in radiological imaging, offering superior spatial resolution, enhanced contrast-to-noise ratio, and reduced radiation dose compared with the conventional energy-integrating detector CT.

aimTo evaluate PCD CT in oncologic imaging, focusing on its role in tumor detection, staging, and treatment response assessment.

methodsWe performed a systematic PubMed search from January 1, 2017 to December 31, 2024, using the keywords "photon-counting CT", "cancer", and "tumor" to identify studies on its use in oncologic imaging. We included experimental studies on humans or human phantoms and excluded reviews, commentaries, editorials, non-English, animal, and non-experimental studies. Study selection followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Out of 175 initial studies, 39 met the inclusion criteria after screening and full-text review. Data extraction focused on study type, country of origin, and oncologic applications of photon-counting CT. No formal risk of bias assessment was performed, and the review was not registered in PROSPERO as it did not include a meta-analysis.

resultsKey findings highlighted the advantages of PCD CT in imaging renal masses, adrenal adenomas, ovarian cancer, breast cancer, prostate cancer, pancreatic tumors, hepatocellular carcinoma, metastases, multiple myeloma, and lung cancer. Additionally, PCD CT has demonstrated improved lesion characterization and enhanced diagnostic accuracy in oncology. Despite its promising capabilities challenges related to data processing, storage, and accessibility remain.

conclusionAs PCD CT technology evolves, its integration into routine oncologic imaging has the potential to significantly enhance cancer diagnosis and patient management.

Indexed as

Cancer detectionComputed tomographyDiagnostic imagingOncologic imagingPhoton-counting detector CTPhoton-counting detector CT applicationsRadiation dose reductionRadiologySpectral imagingTumor characterization

Identifiers

PMID40901346
PMCPMC12400258

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.