Evidence map›Paper›PMID 40901330›Full record

ArticleWorld journal of clinical oncology2025

GPR81 nuclear transportation is critical for cancer growth and progression in lung and other solid cancers.

LiBang Yang, Thomas Kono, Adam Gilbertsen, Yingming Li, Bo Sun, Blake A Jacobson, Sabine Karam, Scott M Dehm, Craig A Henke, Robert A Kratzke

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PubMed Full text at PMC Publisher
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Article in World journal of clinical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

10 authors.

LiBang YangDepartment of Medicine, University of Minnesota, Minnesota 55455, MN, United States. yangx822@umn.edu.
Thomas KonoMinnesota Supercomputing Institute, University of Minnesota, Minnesota 55455, MN, United States.
Adam GilbertsenDepartment of Medicine, University of Minnesota, Minnesota 55455, MN, United States.
Yingming LiMasonic Cancer Center, Department of Medicine, University of Minnesota, Minnesota 55455, MN, United States.
Bo SunDivision of Gastro, Hepatology, Nutrition, Department of Medicine, University of Minnesota, Minnesota 55455, MN, United States.
Blake A JacobsonDivision of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minnesota 55455, MN, United States.
Sabine KaramDivision of Nephrology, Department of Medicine, University of Minnesota, Minnesota 55455, MN, United States.
Scott M DehmMasonic Cancer Center, Department of Medicine, University of Minnesota, Minnesota 55455, MN, United States.
Craig A HenkeDepartment of Medicine, University of Minnesota, Minnesota 55455, MN, United States.
Robert A KratzkeDivision of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minnesota 55455, MN, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe Warburg effect is common in cancers. Lactate and its receptor GPR81 play an important role in cancer progression. It is widely accepted that membrane receptor nuclear translocation plays some novel role in cancer pathology. The mechanism by which the lactate/GPR81 axis regulates cancer malignancy remains unclear.

aimTo elucidate the mechanism of GPR81 nuclear transportation promoted by exogenous lactate.

methodsLung cancer cells were stimulated with exogenous lactate and GPR81 levels were measured by immunofluoresence and western blot analysis in membrane, cytoplasmic, and nuclear fractions. Lung cancer cells were transduced with a mutant GPR81 nuclear localization signal (NLS) construct, wild type GPR81 or empty vector and used to examine how GPR81 nuclear transportation affects lung cancer cells malignancy

resultsIn response to hypoxia/Lactate stimulation, GPR81 translocates and accumulates in the nucleus of lung cancer cells. Functionally, GPR81 nuclear translocation promotes cancer cell proliferation and motility. Depletion of the GPR81 NLS depletes GPR81 nuclear levels and decreases cancer cell growth and invasion

conclusionThe interaction of GPR81 with SFPQ promotes cancer cell malignancy. GPR81 nuclear translocation is critical in conferring cancer progression and may be a potential therapeutic target for limiting cancer progression

Indexed as

Chromatin immunoprecipitation sequencingGPR81Ingenuity pathway analysisInvasionNuclear translocationProteomicsSelf-renewalSolid cancersWarburg effect

Identifiers

PMID40901330
PMCPMC12400187

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