Evidence map›Paper›PMID 40901280›Full record

ArticleNature and science of sleep2025

Arousal Threshold Score: A New Indicator for Examining the Relationship Between Obstructive Sleep Apnea and Overlap Syndrome - A Retrospective Study.

Donghao Wang, Yuting Zhang, Qiming Gan, Xiaofen Su, Yating Chen, Haojie Zhang, Yanyan Zhou, Zhiyang Zhuang, Jingcun Wang, Yutong Ding and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature and science of sleep, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Donghao Wang *State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Sleep Medicine Center, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 510160, People's Republic of China.ORCID 0000-0002-7219-2676
Yuting Zhang *State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Sleep Medicine Center, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 510160, People's Republic of China.
Qiming Gan *State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Sleep Medicine Center, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 510160, People's Republic of China.ORCID 0009-0003-5773-9033
Xiaofen Su *State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Sleep Medicine Center, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 510160, People's Republic of China.ORCID 0000-0001-6354-5794
Yating Chen *State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Sleep Medicine Center, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 510160, People's Republic of China.
Haojie ZhangState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Sleep Medicine Center, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 510160, People's Republic of China.
Yanyan ZhouState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Sleep Medicine Center, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 510160, People's Republic of China.ORCID 0000-0002-6867-4525
Zhiyang ZhuangState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Sleep Medicine Center, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 510160, People's Republic of China.
Jingcun WangState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Sleep Medicine Center, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 510160, People's Republic of China.
Yutong DingState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Sleep Medicine Center, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 510160, People's Republic of China.
Dongxing ZhaoState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Sleep Medicine Center, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 510160, People's Republic of China.
Nuofu ZhangState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Sleep Medicine Center, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 510160, People's Republic of China.ORCID 0000-0003-1998-9958

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: A low arousal threshold (AT) appears to contribute to obstructive sleep apnea (OSA) pathogenesis. However, the role of low AT in OSA and overlap syndrome (OVS) is still unclear. This study is aimed to investigate the value of the AT score, a new method for qualifying AT, for examining the relationship between OSA and OVS, including chronic obstructive pulmonary disease (COPD) and asthma. Methods: In this retrospective study, a total of 3400 adults diagnosed with OSA at a sleep medicine center were finally included. All patients were stratified into low-, high- and very high-AT score groups according to the previous logistic regression for qualifying AT. Multivariate logistic regression was conducted to evaluate the association between AT score and OVS prevalence. We compared this association with that of the apnea hypopnea index (AHI). Results: 40.3%, 42.9% and 16.8% of OSA patients had low-, high- and very high AT score, respectively. Compared with the very high AT score, the low AT score was independently associated with the prevalence of COPD (OR = 2.17, 95% CI = 1.09-4.32) and asthma (OR = 4.54, 95% CI = 2.52-8.17). With decreasing AT score, the adjusted ORs of the comorbidities increased stepwise, particularly in some subgroups based on sex, age and BMI. Conversely, the classification of AHI did not show similar values. Conclusion: In individuals with OSA, low AT is a common pathophysiological feature associated with COPD and asthma. The AT score is a new and effective indicator for evaluating the relationship between OSA and OVS.

Indexed as

arousal thresholdasthmachronic obstructive pulmonary diseaseobstructive sleep apneaoverlap syndromesleep-disordered breathing

Identifiers

PMID40901280
PMCPMC12399886

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.