Evidence map›Paper›PMID 40901211›Full record

ArticleJournal of diabetes research2025

Causal Associations of Iron Status With the Renal Function and Diabetic Nephropathy in Patients With Diabetes Mellitus: A Two-Sample Mendelian Randomization Study.

Ying Zhang, Wujian Peng, Jianrong Huang, Wenchang Zhang, Peishan Jiang, Yuqin He, Meiyun Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ying ZhangDepartment of Endocrinology, Shenzhen Third People's Hospital, The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong Province, China.ORCID https://orcid.org/0009-0007-9203-4345
Wujian PengDepartment of Nephrology, Shenzhen Third People's Hospital, The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong Province, China.ORCID https://orcid.org/0000-0003-1105-0858
Jianrong HuangDepartment of Nephrology, Shenzhen Third People's Hospital, The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong Province, China.ORCID https://orcid.org/0000-0002-6199-1827
Wenchang ZhangDepartment of Endocrinology, Shenzhen Third People's Hospital, The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong Province, China.ORCID https://orcid.org/0009-0001-9970-2138
Peishan JiangDepartment of Endocrinology, Shenzhen Third People's Hospital, The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong Province, China.ORCID https://orcid.org/0009-0009-2766-402X
Yuqin HeDepartment of Endocrinology, Shenzhen Third People's Hospital, The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong Province, China.ORCID https://orcid.org/0009-0000-6937-7488
Meiyun WangDepartment of Endocrinology, Shenzhen Third People's Hospital, The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong Province, China.ORCID https://orcid.org/0009-0009-0708-2524

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study was to explore the causal effect of iron status on renal function and the risk of diabetic nephropathy in diabetic patients. The data on exposures including ferritin, serum iron, transferrin saturation (TSAT), and total iron-binding capacity (TIBC) were obtained from a genome-wide association study (GWAS). The outcomes were diabetic nephropathy, Type 1 diabetes mellitus (T1DM) with renal complications, Type 2 diabetes mellitus (T2DM) with renal complications, estimated glomerular filtration rate (creatinine) (eGFRcrea) in diabetes mellitus, and urinary albumin-to-creatinine ratio (UACR) in diabetes mellitus. The causal associations of exposures and outcomes were analyzed using MR analysis with the inverse variance-weighted (IVW) method as the primary analytical method. Leave-one-out analysis was utilized to find any individual SNP associated with exposures influencing outcomes. Odds ratio (OR) and 95% confidence interval (95% CI) were estimated. The

Indexed as

Diabetes Mellitus, Type 1Diabetes Mellitus, Type 2Diabetic NephropathiesIronKidneyFemaleFerritinsGenome-Wide Association StudyGlomerular Filtration RateHumansMaleMendelian Randomization AnalysisMiddle AgedPolymorphism, Single NucleotideRisk FactorsTransferrinFerritinsIronTransferrincausal effectdiabetic nephropathyferritiniron statusrenal function

Identifiers

PMID40901211
PMCPMC12401605

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.