ReviewAnnals of medicine and surgery (2012)2025
Pancytopenia in HIV-positive patients with congestive heart failure: mechanisms, diagnosis, and treatment approaches.
Review in Annals of medicine and surgery (2012), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Exploring Phosphatidylethanol Cutoffs for Self-Reported Unhealthy Alcohol Use: An International Multi-Site Analysis.Alcohol, clinical & experimental research · 2026Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pancytopenia, characterized by the simultaneous reduction of red blood cells, white blood cells, and platelets, is a significant hematological complication in individuals living with human immunodeficiency virus (HIV). Its presence often reflects disease progression, immune suppression, and concurrent opportunistic infections. When pancytopenia coexists with congestive heart failure (CHF) - a condition increasingly prevalent among HIV-positive patients due to chronic inflammation, antiretroviral therapy (ART)-associated cardiotoxicity, and aging - the clinical burden intensifies, leading to diagnostic and therapeutic dilemmas. This review aims to examine the underlying mechanisms, diagnostic challenges, and management strategies of pancytopenia in HIV-positive patients with CHF. It explores the multifactorial pathophysiology, including direct viral effects on the bone marrow, drug-induced cytopenias, opportunistic infections, nutritional deficiencies, and CHF-related impairments in erythropoietin and thrombopoietin production. Additionally, the review highlights overlapping symptoms that complicate diagnosis and evaluates current treatment options ranging from ART optimization to hematopoietic growth factors and supportive care.
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