ArticleAnnals of medicine and surgery (2012)2025
Rapid recurrence of ovarian mixed sex-cord-stromal tumor associated with DICER1 gene mutation: a case analysis and literature review.
Article in Annals of medicine and surgery (2012), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction and importance: Ovarian tumors are relatively rare in children and adolescent females, with mixed sex-cord-stromal tumors being a specific subtype that has a low incidence and is associated with DICER1 gene mutations. Case presentation: This case report describes a 14-year-old female patient diagnosed with a mixed sex-cord-stromal tumor associated with a DICER1 gene mutation, who had a rapid recurrence. The patient did not receive standardized chemotherapy after the initial surgery, and the tumor recurred within 6 months, leading to a second surgery and chemotherapy. One year of follow-up showed no recurrence. Clinical discussion: This case emphasizes the complexity and biological behavior of mixed sex-cord-stromal tumors, providing important differential diagnostic insights for clinical practice. Moreover, with only three cases of recurrence reported globally, it is crucial for clinicians to take this into consideration. Conclusion: The management experience from this case provides important references for future related research and clinical practice.
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