ArticleAnnals of medicine and surgery (2012)2025
Efficacy and safety of chemoradiotherapy versus chemotherapy for resectable gastric cancer: a systematic review and meta-analysis.
Article in Annals of medicine and surgery (2012), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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14 authors.
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Abstract
Background: Gastric cancer is a leading cause of cancer-related deaths. Surgery combined with adjuvant treatments improves survival. This meta-analysis compares the efficacy of chemoradiotherapy (CRT) vs. chemoimmunotherapy (CT) in resectable gastric cancer. Methods: A comprehensive search across five databases from inception to December 2024 identified studies on efficacy of CRT vs CT in adult patients with resectable gastric cancer. Data were pooled as odds ratio (OR) or hazard ratio (HR) with 95% confidence intervals (CI). Analysis used Review Manager 5.4 with a random-effects model. Results: A total of 29 studies with 20 794 patients were included for further quantitative and qualitative analysis. CRT was associated with significantly higher recurrence-free survival (HR: 0.79; 95%CI: 0.69, 0.91; Conclusion: This meta-analysis concludes a higher efficacy of CRT over CT in improving survival and preventing recurrence, while limiting regional metastasis. Further studies are needed to assess modulation of radiotherapy dosage to reduce the adverse event while maintaining its efficacy.
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