ArticleAnnals of medicine and surgery (2012)2025
The prognostic values of monitoring changes in coagulative, inflammatory, and blood chemistry markers in COVID-19 patient's before and during admission to ICU: a retrospective cohort study.
Article in Annals of medicine and surgery (2012), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: The infection caused by the COVID-19 virus is associated with thromboembolic events and severe inflammatory reactions, significantly impacting the prognosis of infected patients. Numerous studies have indicated that COVID-19 patients often exhibit a hypercoagulable state, disseminated intravascular coagulation, and overwhelming inflammation, particularly in critically ill patients with multiple comorbidities requiring admission to the ICU. This study aims to assess the prognostic significance of alterations in coagulation, inflammatory, and blood chemistry markers in COVID-19 patients both before and during admission to the ICU. Methods: Study design and population: This retrospective observational cohort study was conducted from March 2020 to July 2021 at a single center, including 90 adult patients with confirmed COVID-19 infection requiring ICU admission. Patients were divided into two groups: survivors ( Results: Baseline characteristics: A total of 91 patients were included in the final analysis, comprising 42 survivors (36 males [83.7%], 6 females [16.3%]; median age 54 years [Interquartile Range (IQR): 49-59]; Body Mass Index (BMI) range 23-35) and 48 non-survivors (40 males [83.3%], 8 females [16.7%]; median age 48.5 years [IQR: 45-53]; BMI range 26-40). Overall, the cohort was predominantly male (83.5%) and had a wide range of body mass index. At ICU admission, survivors had slightly higher median platelet counts (257 vs 254 × 10 Conclusion: This study identifies key biomarkers that predict COVID-19 outcomes, emphasizing the association between platelet count and the final fate of COVID-19 patients admitted to the ICU. Elevated ferritin levels predict disease deterioration and poor prognosis, whereas lower glucose levels indicate a better prognosis.
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