Evidence map›Paper›PMID 40901149›Full record

ReviewAnnals of medicine and surgery (2012)2025

The synergistic potential of camrelizumab and rivoceranib in advanced hepatocellular carcinoma: a review of current evidence.

Khadija Ahmed, Abdur Rehman, Bhawna Devi, Sheharyar Ul Haq, Anousheh Malak, Munawara Zeb, Anupama Ariyasiri, Rohail Memon, Zoya Kashif, Zarjana Shamsher and 4 more

Abstract readReview
In one paragraph

Review in Annals of medicine and surgery (2012), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Khadija AhmedDepartment of Medicine, Dow Medical College, Karachi, Pakistan.ORCID https://orcid.org/0000-0002-9310-062X
Abdur RehmanDepartment of Medicine, Saidu Medical College, Swat, Pakistan.ORCID https://orcid.org/0009-0006-0695-6347
Bhawna DeviDepartment of Medicine, Ziauddin Medical College, Karachi, Pakistan.ORCID https://orcid.org/0009-0009-4399-4088
Sheharyar Ul HaqDepartment of Medicine, Rahbar Medical and Dental College, Lahore, Pakistan.
Anousheh MalakDepartment of Medicine, Saidu Medical College, Swat, Pakistan.ORCID https://orcid.org/0009-0006-4857-3942
Munawara ZebDepartment of Medicine, Saidu Medical College, Swat, Pakistan.ORCID https://orcid.org/0009-0005-4666-6806
Anupama AriyasiriDepartment of Medicine, Dow International Medical College, Karachi, Pakistan.ORCID https://orcid.org/0009-0002-4082-2888
Rohail MemonDepartment of Medicine, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan.ORCID https://orcid.org/0009-0009-8678-6043
Zoya KashifDepartment of Medicine, Jinnah Sindh Medical University, Karachi, Pakistan.ORCID https://orcid.org/0009-0001-0250-7265
Zarjana ShamsherDepartment of Medicine, Saidu Medical College, Swat, Pakistan.ORCID https://orcid.org/0009-0006-9922-2907
Bahar UllahDepartment of Medicine, Saidu Medical College, Swat, Pakistan.ORCID https://orcid.org/0009-0003-7183-1653
Warisha KanwalDepartment of Medicine, Karachi Medical and Dental College, Karachi, Pakistan.ORCID https://orcid.org/0000-0002-3092-922X
Muhammad HasanainDepartment of Medicine, Dow Medical College, Karachi, Pakistan.ORCID https://orcid.org/0000-0001-9214-7840
Mohammed Mahmmoud Fadelallah EljackDepartment of Medicine, Community Department, University of Bakht Alruda, Ad Duwaym, Sudan.ORCID https://orcid.org/0000-0002-2370-9368

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Camrelizumab, a PD-1 inhibitor, and rivoceranib, a VEGFR tyrosine kinase inhibitor, have emerged as a promising combination therapy for advanced or unresectable hepatocellular carcinoma (HCC). This review explores the clinical efficacy and therapeutic potential of this dual treatment approach. A comprehensive literature search was conducted using PubMed/MEDLINE and Google Scholar to evaluate key clinical trials, including the pivotal CARES-310 trial. The final analysis of CARES-310 demonstrated a median overall survival (OS) of 23.8 months with camrelizumab plus rivoceranib, significantly higher than the 15.2 months observed with sorafenib (HR, 0.64; 95% CI, 0.52-0.79;

Indexed as

aptinibcamrelizumabhepatocellular carcinoma (HCC)rivoceranib

Identifiers

PMID40901149
PMCPMC12401341

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.