ArticleFrontiers in veterinary science2025
Gastrointestinal flora and serum metabolomic elucidation of
Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: This study addresses the global challenge of subclinical bovine mastitis (SCBM) in dairy cows, a prevalent disease causing substantial economic losses, by investigating the mechanistic basis of Methods: Initially, the active components of Results: ARWD administration dose-dependently improved milk yield and protein content while reducing somatic cell counts. Serum pro-inflammatory cytokines (TNF-α, IL-6, IL-1β) decreased, contrasting with increases in immunoglobulins (IgA, IgM, IgG) and enhanced superoxide dismutase activity. Microbiota restructuring featured ruminal enrichment of Bifidobacterium and fecal dominance of Rikenellaceae_RC9_gut_group, coupled with suppression of pro-inflammatory taxa (e.g., Christensenellaceae_R-7_group). Metabolomic analysis identified four ARWD-responsive biomarkers, notably Spirotaccagenin and Pelanin, operating through linoleic acid metabolism and phospholipase D signaling pathways. Strong correlations linked microbial shifts to improved lactation parameters and reduced inflammation. Conclusion: The findings establish that ARWD alleviates SCBM through coordinated microbiota remodeling and metabolic reprogramming, specifically enhancing antioxidant defenses, restoring mammary barrier integrity, and modulating immune-inflammation crosstalk, with optimal efficacy at 0.4 g·kg
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