Evidence map›Paper›PMID 40901001›Full record

ArticleFrontiers in cellular and infection microbiology2025

Impact of 2D versus 3D fibroblast models on

Rebecca Thereza Silva Santa Brígida, Adeniele Lopes da Cruz Carneiro, Felipe Tuji de Castro Franco, Brenda Furtado Costa, Ana Paula Drummond Rodrigues

Abstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rebecca Thereza Silva Santa Brígida *Multiuser Laboratory of Cell Biology and Ultrastructure, Evandro Chagas Institute, Belém, Pará, Brazil.
Adeniele Lopes da Cruz Carneiro *Multiuser Laboratory of Cell Biology and Ultrastructure, Evandro Chagas Institute, Belém, Pará, Brazil.
Felipe Tuji de Castro FrancoMultiuser Laboratory of Cell Biology and Ultrastructure, Evandro Chagas Institute, Belém, Pará, Brazil.
Brenda Furtado CostaMultiuser Laboratory of Cell Biology and Ultrastructure, Evandro Chagas Institute, Belém, Pará, Brazil.
Ana Paula Drummond RodriguesMultiuser Laboratory of Cell Biology and Ultrastructure, Evandro Chagas Institute, Belém, Pará, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The protozoan Methods: 3T3 fibroblasts were exposed to promastigotes of both Results: Higher adhesion of Conclusions: These novel findings reveal that distinct Leishmania species utilize specialized invasion strategies, adapting to both host cell type and experimental conditions. This underscores the role of species-specific biological traits in modulating host cell entry mechanisms, which may, in turn, influence the varied clinical manifestations associated with each species.

Indexed as

ActinsFibroblastsLeishmaniaLeishmania braziliensisrab5 GTP-Binding Proteins3T3 CellsAnimalsCell AdhesionMiceMicroscopy, ConfocalActinsrab5 GTP-Binding Proteins3D cell cultureactin cytoskeletonfibroblastsLeishmaniaparasite invasionRab5

Identifiers

PMID40901001
PMCPMC12399602

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.