ArticleFrontiers in cellular and infection microbiology2025
Vaginal microbiota: different roles of lactobacilli and community instability in chronic vulvovaginal discomfort.
Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Vaginal Microbiome Profiles and Reproductive Outcomes: Implications for Natural Conception and Assisted Reproduction.Cureus · 2026Review
- Bidirectional Interactions Between Cervicovaginal Microbiota and Human Papillomavirus Drive Persistence and Disease Progression.International journal of molecular sciences · 2026Review
- Diagnostic performance of deep learning-based vaginal microecological morphology assessment for bacterial vaginosis and vulvovaginal candidiasis.Frontiers in microbiology · 2026Article
- Integrating microbiome insights into cervical cancer.Frontiers in medicine · 2026Review
- Population‑Specific Diversity of Dominant VaginalInternational journal of women's health · 2026Article
- Comparative Characterization of Vaginal and Gut Microbiota in Late-Pregnancy Women with or Without Group B Streptococcus Colonization.Microorganisms · 2025Article
- Comprehensive analysis of vaginal microbiota, metabolites, and inflammatory factors in preterm and term pregnancies.Frontiers in microbiology · 2025Article
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Authors and funding
13 authors.
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Abstract
Background: Chronic vulvovaginal discomfort (CVD) is a complex syndrome with many unresolved questions regarding its etiology, diagnosis, and management in relation to the vaginal microbiota. Methods: Cervicovaginal fluid of 91 CVD patients and 35 healthy controls was obtained at the beginning and end of the follow-up period. The bacterial community state types (CST) in the vagina were assessed using next-generation sequencing (NGS). CVD patients were divided into four study groups by etiology: non-specific, yeast, bacterial, and mixed. Results: The vaginal microbiota was characterized by 1) predominance of CST3 in all study groups, 2) a relatively higher proportion of CST2 (29.2%) and CST4 (20.0%) in the non-specific group and controls, respectively, 3) lack of CST4 (4.0%) in the yeast group, and 4) an effect of clinical status (CVD vs. health) on CST stability and microbiota composition. The vaginal environment was shaped by lactobacilli except for CST4. CVD patients had a higher proportion of G-positive cocci than controls; the non-specific group had significantly higher Conclusion: Our results revealed an opposing trend in the abundance of
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