ArticleFrontiers in neuroscience2025
Effects of all-trans retinoic acid on glutamate receptor expression and dendritic spine density in the hypothalamus of rats.
Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Increasing evidence suggests that all-trans retinoic acid (ATRA) contributes to the pathogenesis of depression. Although numerous studies have emphasized the role of hippocampal glutamatergic transmission and dendritic spine abnormalities in ATRA-induced depression, it remains unclear whether changes in hypothalamic glutamatergic transmission and dendritic spine density also contribute to its development. This study investigates the effects of ATRA treatment on glutamate receptor expression and dendritic spine density in the hypothalamus of rats. We found that prolonged ATRA exposure induced depression-like behaviors, as evidenced by altered behavior in standard tests. These behavioral changes were accompanied by significant upregulation of retinoic acid receptor
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