ReviewCancer diagnosis & prognosis
The Prognostic Role of Lymphatic Vessel Density in Papillary Thyroid Carcinoma: A Systematic Review and Meta-analysis.
Review in Cancer diagnosis & prognosis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Posterior minimal extrathyroidal extension as an independent risk factor for lateral lymph node metastasis in papillary thyroid carcinoma: a retrospective study based on a nomogram prediction model.Frontiers in endocrinology · 2026Article
- Effects of Isthmus Topography on the Molecular Characteristics ofCancer genomics & proteomicsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background/Aim: Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer accounting for 75-85% of cases. Despite its favorable prognosis, 30-50% of patients develop regional lymph node metastases. Lymphatic vessel density (LVD) is a potential predictor of tumor progression, metastasis, and patient survival in PTC. This systematic review and meta-analysis evaluate the prognostic significance of LVD in PTC, focusing on intratumoral and peritumoral LVD and their association with nodal metastasis. Materials and Methods: A systematic review and meta-analysis were conducted following PRISMA guidelines and the Cochrane Handbook. Eligible studies included patients with PTC who underwent tumor resection and had LVD assessed Results: A total of 21 studies were identified, with nine meeting eligibility criteria. Meta-analysis demonstrated a significant association between high overall LVD and increased nodal metastasis (summary mean difference: 2.64; 95%CI=1.45, 3.82; Conclusion: This meta-analysis highlights the prognostic role of overall LVD in predicting nodal metastasis in PTC. However, intratumoral and peritumoral LVD did not show a significant correlation, indicating the need for further research. Standardization of LVD assessment and integration with molecular markers could enhance risk stratification and personalized treatment approaches in PTC management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.