ArticleCancer diagnosis & prognosis
Treatment Response and Survival in Thyroid Transcription Factor-1 Negative Non-squamous Non-small Cell Lung Cancer.
Article in Cancer diagnosis & prognosis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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9 authors.
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Abstract
Background/Aim: In patients with thyroid transcription factor-1 (TTF-1)-negative non-squamous non-small cell lung cancer (NS-NSCLC), the efficacy of pemetrexed and immunotherapy has been reported to be limited, and the optimal treatment strategy remains unclear. Recent studies have suggested that bevacizumab may improve outcomes; however, robust evidence is still lacking. This study aimed to clarify the clinical characteristics of responders to first-line treatment in patients with TTF-1-negative NS-NSCLC and identify predictive factors for treatment response, proposing an optimal treatment strategy. Patients and Methods: A retrospective analysis was conducted on patients with TTF-1-negative NS-NSCLC. Patients were classified into responder and non-responder groups based on first-line treatment efficacy, and predictive factors associated with treatment response were analyzed. Results: Among the 29 patients included, seven (24.1%) were classified as responders. Platinum-based combination therapy was significantly more common in the responder group ( Conclusion: In the treatment of TTF-1-negative NS-NSCLC, platinum-based combination therapy, particularly with the addition of bevacizumab, improved response rates and led to prolonged survival.
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