Evidence map›Paper›PMID 40900866›Full record

ArticleWorld journal of methodology2025

Association of neutrophil-lymphocyte ratio with cardiovascular and all-cause mortality in patients receiving chronic hemodialysis: Systematic review and meta-analysis.

Roopeessh Vempati, Nanush Damarlapally, Srivatsa Surya Vasudevan, Viral Patel, Prathibha Banda, Denise Mourad, Harshavardhan Polamarasetty, Gaurav Mathur, Afrasayab Khan, Rupak Desai and 2 more

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Article in World journal of methodology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Roopeessh VempatiInternal Medicine, Trinity Health Oakland Hospital, Pontiac, MI 48341, United States.
Nanush DamarlapallyHealth Sciences, Houston Community College-Coleman Campus, Houston, TX 77030, United States.
Srivatsa Surya VasudevanDepartment of Otolaryngology, Louisiana State University Health Sciences Center, Shreveport, LA 70112, United States.
Viral PatelInternal Medicine, Baptist Hospital of South Texas, Beaumont, TX 77701, United States.
Prathibha BandaInternal Medicine, Gandhi Medical College and Hospital, Secunderabad 500003, Telangāna, India.
Denise MouradInternal Medicine, Central Michigan University, Saginaw, MI 48602, United States.
Harshavardhan PolamarasettyBiomedical Engineering, University of Houston, Houston, TX 77004, United States.
Gaurav MathurDepartment of Internal Medicine, Connecticut Institute for Communities, Danbury, CT 06810, United States.
Afrasayab KhanInternal Medicine, Central Michigan University, Saginaw, MI 48602, United States.
Rupak DesaiOutcomes Research, Independent Researcher, Atlanta, GA 30079, United States.
Iqbal RatnaniDepartment of Anesthesiology, Houston Methodist, Houston, TX 77030, United States.
Salim SuraniDepartment of Medicine and Pharmacology, Texas A&M University, College Station, TX 77843, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe neutrophil-lymphocyte ratio (NLR) has been proposed as a potential prognostic marker for mortality outcomes in various conditions, yet its association with chronic hemodialysis (HD) remains underexplored. We aim to study its utility by conducting a meta-analysis of this specific population.

aimTo determine whether elevated NLR is associated with all-cause mortality (ACM) and cardiovascular mortality (CVM) in patients undergoing chronic HD.

methodsA comprehensive search from PubMed, Google Scholar, and Scopus identified studies showing the association between NLR and mortality outcomes in patients with chronic HD. Random-effects models with 95%CIs were employed to pool adjusted hazard ratios (aHRs), odds ratios (ORs), and

results19 studies comprising 9047 patients with a mean age of 59.5 ± 5.86 years and a mean follow-up duration of 46.7 months were included in our study. Our meta-analysis revealed a significant association between NLR > 2.5 and increased risks of ACM (aHR: 1.25, 95%CI: 1.14-1.37,

conclusionThis meta-analysis suggests that elevated NLR may serve as a useful prognostic marker for ACM and CVM in patients on chronic HD and can be useful in planning for the prevention of mortality-related strategies.

Indexed as

All-cause mortalityCardiovascular mortalityChronic hemodialysisDialysis-associated cardiovascular diseaseDialysis outcomesHematological biomarkersInflammationInflammatory markersNeutrophil-lymphocyte ratio

Identifiers

PMID40900866
PMCPMC12400326

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