Evidence map›Paper›PMID 40900864›Full record

ArticleWorld journal of methodology2025

Prognostic significance of hyponatremia in peripartum cardiomyopathy.

Kamilu M Karaye, Naser A Ishaq, Hadiza Saidu, Sulaiman A Balarabe, Mohammed Abdullahi Talle, Muhammad S Isa

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Article in World journal of methodology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Kamilu M KarayeDepartment of Medicine, Aminu Kano Teaching Hospital, Kano 700233, Nigeria.
Naser A IshaqDepartment of Medicine, Aminu Kano Teaching Hospital, Kano 700233, Nigeria.
Hadiza SaiduDepartment of Medicine, Bayero University, Kano 700006, Nigeria.
Sulaiman A BalarabeDepartment of Medicine, Muhammad Abdullahi Wase Specialist Hospital, Kano 700213, Nigeria.
Mohammed Abdullahi TalleDepartment of Medicine, University of Maiduguri Teaching Hospital, Maiduguri 600230, Borno, Nigeria.
Muhammad S IsaDepartment of Medicine, Ahmadu Bello University Teaching Hospital, Zaria 810107, Kaduna, Nigeria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHyponatremia is the most common electrolyte imbalance, however the prognostic significance of hyponatremia in peripartum cardiomyopathy (PPCM) remains unclear.

aimTo assess the prognostic significance of hyponatremia in PPCM patients.

methodsWe consecutively recruited patients with PPCM from 14 sites in Nigeria and followed them up for a median of 18 months. Serum sodium was measured at baseline, and patients with hyponatremia (< 135 mmol/L) were compared with those with normal sodium levels. Cox proportional hazards regression models were developed to identify factors associated with all-cause mortality.

resultsOf the 191 PPCM patients recruited, 90 (47.1%) had hyponatremia at presentation. All-cause mortality among the hyponatremic patients (24/90; 26.7%) was significantly higher than among patients with normal serum sodium (7/101; 6.9%) (

conclusionHyponatremia was common in our cohort of PPCM patients, and was independently associated with a threefold increased risk for all-cause mortality. Hypotension and a LVEF below 25% at presentation were also independent predictors of mortality.

Indexed as

HyponatremiaOutcomes: PEACE registryPeripartum cardiomyopathy

Identifiers

PMID40900864
PMCPMC12400343

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