ArticleWorld journal of gastroenterology2025
Diagnostic accuracy of dual-layer spectral computed tomography virtual monoenergetic imaging with multiplanar reformation for T-staging of colorectal cancer.
Article in World journal of gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Deep learning reconstruction for 40-keV virtual monoenergetic CT of colon cancer: evaluation of image quality and edge sharpness.Abdominal radiology (New York) · 2026Article
- Dual-Layer Spectral CT for Locoregional Assessment of Rectal Cancer: A Comparison with MRI in a Pilot Study.Diagnostics (Basel, Switzerland) · 2026Article
- Development and validation of a machine learning-based radiomics model using 45-keV virtual monoenergetic images for differentiating fat-poor angiomyolipoma from clear cell renal cell carcinoma.Translational andrology and urology · 2026Article
- Research progress of the clinical application of dual-layer spectral computed tomography in gastrointestinal malignancies.World journal of radiology · 2026Review
- Spectral CT imaging in colorectal cancer: current applications, limitations, and future perspectives.Insights into imaging · 2026Review
- Comparative accuracy of spectral computed tomography and conventional computed tomography in colorectal cancer staging.Frontiers in oncology · 2026Article
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Authors and funding
7 authors.
Funding
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Abstract
backgroundAccurate preoperative T staging is essential for determining optimal treatment strategies in colorectal cancer (CRC). Low-keV virtual monoenergetic images (VMIs) have been shown to enhance lesion conspicuity. This study aimed to assess the diagnostic value of dual-layer spectral computed tomography (CT)-derived VMIs, in combination with multiplanar reformation (MPR) and evaluation of peritumoral fat stranding (PFS), for improving the accuracy of T staging in CRC.
aimTo assess the diagnostic performance of dual-layer spectral CT (DLSCT) VMIs, particularly at low energy levels, and their integration with personalized MPR for preoperative T staging of CRC.
methodsIn this retrospective study, 157 patients with pathologically confirmed CRC (mean age: 63.5 ± 12.1 years) underwent DLSCT within 1 week before surgery. VMIs ranging from 40 keV to 70 keV (at 10 keV intervals) and conventional polyenergetic images (PEIs) were reconstructed. Objective image quality parameters, including image noise, signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR), were quantified, alongside subjective image quality scores using a 5-point Likert scale. Interobserver agreement was evaluated using
resultsLow-keV VMIs (40-70 keV) demonstrated significantly higher SNR and CNR than PEIs (all
conclusionDLSCT VMIs at 40-50 keV significantly enhanced image quality and improved preoperative T staging accuracy of CRC when combined with MPR. These findings underscored the clinical value of low-keV spectral imaging in tailoring individualized treatment strategies.
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