Diagnostic value of Ep300 and FOXO4 proteins in acute ischemic stroke: preliminary findings from a case-control study.

Emre Bülbül, İbrahim Toker, Halime Dana, Mehmet Doğan, İbrahim Mercan, Burcu Çoşkun Işık, Elif Funda Şener

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Article in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Emre BülbülEmergency Medicine, Erciyes University, Kayseri, Turkey.

İbrahim TokerEmergency Medicine, Kayseri City Hospital, Kayseri, Turkey.

Halime DanaDepartment of Medical Biology, Erciyes University Genome and Stem Cell Center (GENKOK), Erciyes University, Kayseri, Turkey.

Mehmet DoğanPublic Health, Vocational Health College, Erciyes University, Kayseri, Turkey.

İbrahim MercanEmergency Medicine, Erciyes University, Kayseri, Turkey.

Burcu Çoşkun IşıkEmergency Medicine, Erciyes University, Kayseri, Turkey.

Elif Funda ŞenerDepartment of Medical Biology, Erciyes University Genome and Stem Cell Center (GENKOK), Erciyes University, Kayseri, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Stroke is a leading cause of death and disability worldwide, and there is still a lack of specific and sensitive biomarkers for its diagnosis. Objective: This study aimed to investigate the diagnostic value of FOXO4 and Ep300 proteins in acute ischemic stroke patients who visited the emergency department. Methods: Patients were consecutively included in the study. The amount of Ep300 and FOXO4 proteins was determined using an enzyme-linked immunosorbent assay (ELISA). Receiver operator characteristic (ROC) analyses of FOXO4 and Ep300 proteins were performed. Results: The study was conducted on a total of 39 acute ischemic stroke patients, 17 females and 22 males, with a mean age of 66.9 ± 11 years. Seventeen females and 23 male control were also included. The discriminative ability of Ep300 protein was not statistically significant ( Conclusions: The study's findings suggest that FOXO4 protein could potentially serve as a valuable biomarker in the diagnosis of stroke in acute ischemic stroke patients.

Indexed as

Cell Cycle ProteinsE1A-Associated p300 ProteinForkhead Transcription FactorsIschemic StrokeAgedBiomarkersCase-Control StudiesEnzyme-Linked Immunosorbent AssayFemaleHumansMaleMiddle AgedPredictive Value of TestsROC CurveSensitivity and SpecificityBiomarkersCell Cycle ProteinsE1A-Associated p300 ProteinEP300 protein, humanForkhead Transcription FactorsFOXO4 protein, humanEp300 proteinFoxo4 proteinHumanIschemic stroke

Identifiers

PMID40900757

DOI10.7717/peerj.19970

PMCPMC12401024

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