Effects of combined aerobic-resistance training on health-related quality of life and stress in sedentary adults.

Introduction: Poor quality of life and psychological stress have been associated with worse clinical outcomes, including anxiety and depression disorders, cardiovascular diseases, metabolic syndrome, type 2 diabetes, and premature mortality. Evidence suggested that physically active adults were more likely to report better quality of life and increased capacity to deal with stress, compared to their sedentary peers. This study examines the effects of 16 weeks of combined aerobic and resistance exercise training on health-related quality of life (HRQoL) and stress levels in sedentary adults. Methods: This study involved previously sedentary middle-aged workers (n = 36), randomized, and allocated into control (n = 18) and exercise (n = 18) groups. The exercise group performed 16 weeks of combined exercise training for 75 min, three times/week. The HRQoL was assessed using the SF-36 survey and Satisfaction with Life Scale. Stress levels were assessed subjectively using the Perceived Stress Scale and objectively by the salivary cortisol and alpha-amylase concentrations. Intra- and inter-group analysis were performed using a mixed ANOVA or Friedman's test. Results: In relation to SF-36 results, a significant improvement in the mental component summary ( Discussion: The present study's findings may have important clinical implications because they show that middle-aged sedentary workers are likely to benefit from adopting a regular combined exercise training regimen to promote better HRQoL (i.e., mental health component) and wellbeing. Clinical Trial Registration: clinicaltrials.gov, identifier NCT04868240.