Evidence map›Paper›PMID 40900738›Full record

ArticleStem cells international2025

Facial Nerve Regeneration in Immunodeficient Rats Using a Bio 3D Conduit Fabricated From Human Dental Pulp Stem Cells.

Yuri Matsui-Chujo, Ayano Hatori, Monika Nakano, Yuki Kanno, Ryosuke Ikeguchi, Tomoki Aoyama, Kazuaki Fujita, Yudai Miyazaki, Yoko Torii, Shizuka Akieda and 2 more

Abstract read
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In one paragraph

Article in Stem cells international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yuri Matsui-ChujoDepartment of Oral and Maxillofacial Surgery, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.
Ayano HatoriDepartment of Oral and Maxillofacial Surgery, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.
Monika NakanoDepartment of Oral and Maxillofacial Surgery, Tokyo Women's Medical University, 8-1 Kawadacho, Shinjuku-ku, Tokyo 162-0054, Japan.
Yuki KannoDepartment of Oral and Maxillofacial Surgery, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.
Ryosuke IkeguchiDepartment of Rehabilitation Medicine, Kyoto University Graduate School of Medicine, Shogoin Kawara-cho 54, Sakyo-ku, Kyoto 606-8507, Japan.ORCID https://orcid.org/0000-0003-4525-7849
Tomoki AoyamaHuman Health Sciences, Graduate School of Medicine, Kyoto University, Shogoin Kawara-cho 54, Sakyo-ku, Kyoto 606-8507, Japan.
Kazuaki FujitaDepartment of Rehabilitation Medicine, Kyoto University Graduate School of Medicine, Shogoin Kawara-cho 54, Sakyo-ku, Kyoto 606-8507, Japan.
Yudai MiyazakiCyfuse Biomedical K.K., South Tower-1F., Sumitomo Fudosan, 3-5-27Mita, Minato-ku, Tokyo 108-6301, Japan.
Yoko ToriiCyfuse Biomedical K.K., South Tower-1F., Sumitomo Fudosan, 3-5-27Mita, Minato-ku, Tokyo 108-6301, Japan.
Shizuka AkiedaCyfuse Biomedical K.K., South Tower-1F., Sumitomo Fudosan, 3-5-27Mita, Minato-ku, Tokyo 108-6301, Japan.
Daichi ChikazuDepartment of Oral and Maxillofacial Surgery, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.
Yoko Kawase-KogaDepartment of Oral and Maxillofacial Surgery, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.ORCID https://orcid.org/0000-0003-4746-7102

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor surgery or trauma in the maxillofacial region may cause injuries to peripheral nerves, such as facial nerves. The gold standard of treatment for peripheral nerve injury has been autologous nerve grafting. Since new peripheral nerve regeneration technologies are required, three-dimensional (3D) structures fabricated only from cells by using Bio 3D printers are attracting attention. Dental pulp stem cells (DPSCs) are a promising option as a cell source because of their high clonogenic, proliferative, and multidifferentiation potentials. In this study, nerve conduits were fabricated from DPSCs using a Bio 3D printer, and their potential for nerve regeneration was evaluated in a rat facial nerve injury model. DPSCs were obtained from wisdomteeth of patients and cultured. A 5 mm Bio 3D conduit was fabricated by using a Bio 3D printer. Six F344 rnu-/rnu- rats with immune deficiency (10 weeks old, body weight: 190-240 g) were divided into two groups: a Bio 3D group (

Indexed as

bio 3D printerdental pulp stem cellsfacial nervenerve conduitnerve regenerationperipheral nerve

Identifiers

PMID40900738
PMCPMC12401602

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.