Evidence map›Paper›PMID 40900636›Full record

ArticleThe Journal of general virology2025

SARS-CoV-2 infection of substantia nigra pars compacta induces expression of miR-330-5p at 10 days post-infection.

Bishwa R Pokharel, Niska Majumdar, Frank Williams, Abigail Dickerson, Hannah Croy, Jeffrey B Eells, Alessandro Didonna, Srinivas Sriramula, Paul P Cook, Shaw M Akula

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of general virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bishwa R PokharelDepartment of Microbiology & Immunology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA.
Niska MajumdarDepartment of Microbiology & Immunology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA.
Frank WilliamsDepartment of Microbiology & Immunology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA.
Abigail DickersonDepartment of Microbiology & Immunology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA.
Hannah CroyDepartment of Molecular Biomedical Sciences, College of Veterinary Medicine, NC State University, Raleigh, NC 27606, USA.
Jeffrey B EellsDepartment of Molecular Biomedical Sciences, College of Veterinary Medicine, NC State University, Raleigh, NC 27606, USA.
Alessandro DidonnaDepartment of Anatomy and Cell Biology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA.
Srinivas SriramulaDepartment of Pharmacology & Toxicology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA.
Paul P CookDepartment of Internal Medicine, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA.
Shaw M AkulaDepartment of Microbiology & Immunology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been linked to several neurological symptoms in coronavirus disease 2019 (COVID-19) patients; however, the molecular mechanisms underlying virus-induced neuroinflammation are not well identified. For example, the effect of SARS-CoV-2 infection of the substantia nigra pars compacta (SNpc) of the midbrain has not been addressed, in spite of its importance in dopaminergic signalling and neurodegenerative abnormalities. The purpose of this study was to understand the SARS-CoV-2-induced inflammatory response in the SNpc region of the brain. We inoculated (intranasally) transgenic mice expressing human ACE2 under control of the human keratin 18 promoter (K18-hACE-2 mice) with a 4×10

Indexed as

COVID-19MicroRNAsSARS-CoV-2Substantia NigraAngiotensin-Converting Enzyme 2AnimalsDisease Models, AnimalHumansMiceMice, TransgenicMicrogliaACE2 protein, humanAngiotensin-Converting Enzyme 2MicroRNAslong COVIDmidbrainmiR-330-5pneuroinflammationsevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Identifiers

PMID40900636
PMCPMC12451610

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.