Evidence map›Paper›PMID 40900516›Full record

Observational studyEpidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil2025

Variability in public procurement prices for Group 1A drugs in the specialized pharmaceutical component: an observational study, 2013-2022.

Paula Rossignoli, Roberto Pontarolo, Fernando Fernandez-Llimos

Abstract readObservational StudyComparative Study
In one paragraph

Observational study in Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Paula RossignoliUniversidade Federal do Paraná, Programa de Pós-Graduação em Assistência Farmacêutica, Curitiba, PR, Brasil.ORCID http://orcid.org/0000-0002-8691-7359
Roberto PontaroloUniversidade Federal do Paraná, Departamento de Farmácia, Curitiba, PR, Brasil.ORCID http://orcid.org/0000-0002-7049-4363
Fernando Fernandez-LlimosUniversidade do Porto, Faculdade de Farmácia, Porto, Portugal.ORCID http://orcid.org/0000-0002-8529-9595

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo assess the difference in acquisition prices of Group 1A drugs in the Specialized Pharmaceutical Component between purchases made by the Brazilian Ministry of Health and those made by the Paraná State Health Department.

methodsThis was a retrospective observational study comparing prices of medications acquired centrally by the Brazilian Ministry of Health and those acquired by the State of Paraná to meet court orders or to supply supplementary lists, from 2013 to 2022. The weighted average acquisition price was calculated for each procurement source, per year, based on data from the Paraná Health Department management information system. The ratio between Paraná's and the Brazilian Ministry of Health's weighted average prices was calculated, as well as the hypothetical cost of Paraná's purchases had they been made at the Ministry's prices. Total overpricing in Paraná's acquisitions was also calculated.

resultsA total of 500 price comparisons were conducted, covering 116 different drug presentations. In 84.6% of the comparisons, Paraná's prices exceeded those of the Ministry of Health. For seven pharmaceutical presentations, the state price was more than 10 times higher than the federal price, reaching as high as 47.32 times in the most extreme case. Overall, Paraná's expenditures exceeded by more than BRL 200 million the amount that would have been paid at the Ministry's prices, resulting in 55.7% overpricing.

conclusionThere was considerable variation between prices of drugs acquired centrally by the Brazilian Ministry of Health and those acquired by the state of Paraná. To enhance cost-effectiveness within the Brazilian National Health System, mechanisms for centralized price negotiation or procurement should be further explored.

Indexed as

CommerceDrug CostsNational Health ProgramsBrazilHumansPharmaceutical PreparationsRetrospective StudiesPharmaceutical Preparations

Identifiers

PMID40900516
PMCPMC12404603

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.