ArticleJapanese journal of ophthalmology2025
Identifying novel risk factors for ocular lesions in patients with fungemia and determining the efficacy of routine screening.
Article in Japanese journal of ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo identify novel risk factors associated with the presence of fungal ocular lesions in patients with fungemia and to evaluate the validity and efficacy of routine screening. STUDY
designRetrospective study
methodsThe medical records of 198 patients diagnosed with fungemia by blood culture at 3 medical centers in Japan between March 2017 and April 2022 were analyzed. Ocular lesions were categorized as possible, probable, or proven, according to previously established definitions. The primary outcome measure was prevalence of ocular lesions. Secondary outcomes included the classification of ocular lesions and mortality.
resultsAmong the 198 patients with fungemia, 115 underwent fundus examination. Ocular lesions were observed in 40 patients (34.8%), with 16 classified as probable and 24 as possible. Among those with positive ocular lesions, 5 (12.5%) complained of ocular symptoms, whereas 21 (52.5%) had impaired consciousness. Impaired consciousness was associated with an increased prevalence of ocular lesions (odds ratio [OR], 2.70). Bedside ophthalmic consultations were associated with the classification of ocular lesions (OR, 0.0485). Positive ocular lesions and echinocandin administration were associated with mortality (ORs, 3.180 and 4.140, respectively).
conclusionOur study results demonstrate that impaired consciousness is an independent risk factor for ocular lesions. Moreover, the presence of ocular lesions was determined to be an independent factor associated with mortality, highlighting the importance of detecting these lesions in systemic management. Based on these findings, we recommend dilated fundus examination by ophthalmologists in patients with fungemia who do not complain of visual symptoms.
Indexed as
Identifiers
40900382What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.