Evidence map›Paper›PMID 40900364›Full record

ArticleDigestive diseases and sciences2026

Aerobic Exercise Training Leads to MASH Resolution as Defined by the MASH Resolution Index.

Theja Channapragada, Sarah Batra, Breianna L Hummer, Vernon M Chinchilli, Daniel Huang, Rohit Loomba, Ian R Schreibman, Jonathan G Stine

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Digestive diseases and sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03518294 (NASH Fitness Intervention in Thrombosis Trial), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03518294 nacompletednot on this map

NASH Fitness Intervention in Thrombosis Trial (NASHFit)

TypeinterventionalSponsorMilton S. Hershey Medical CenterRan2018 to 2021Enrolled28ConditionsLiver Diseases, Blood Disorder, Digestive System DiseaseArmsAerobic Exercise
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Theja ChannapragadaDepartment of Medicine, Penn State Health-Milton S. Hershey Medical Center, Hershey, PA, USA.
Sarah BatraDivision of Gastroenterology and Hepatology, Department of Medicine, Penn State Health- Milton S. Hershey Medical Center, 500 University Drive, Hershey, PA, 17033, USA.
Breianna L HummerDivision of Gastroenterology and Hepatology, Department of Medicine, Penn State Health- Milton S. Hershey Medical Center, 500 University Drive, Hershey, PA, 17033, USA.
Vernon M ChinchilliDepartment of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA.
Daniel HuangDivision of Gastroenterology and Hepatology, Department of Medicine, University of California San Diego, La Jolla, CA, USA.
Rohit LoombaDivision of Gastroenterology and Hepatology, Department of Medicine, University of California San Diego, La Jolla, CA, USA.
Ian R SchreibmanDivision of Gastroenterology and Hepatology, Department of Medicine, Penn State Health- Milton S. Hershey Medical Center, 500 University Drive, Hershey, PA, 17033, USA.
Jonathan G StineDivision of Gastroenterology and Hepatology, Department of Medicine, Penn State Health- Milton S. Hershey Medical Center, 500 University Drive, Hershey, PA, 17033, USA. jstine@pennstatehealth.psu.edu.

Funding

Establishing the mechanism of benefit and dose of exercise required to improve liver histology in patients with nonalcoholic steatohepatitisK23DK131290 · NIDDK · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI STINE, JONATHAN G · 2022 to 2025
$801k
National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health K23DK131290NIDDK NIH HHS K23 DK131290NIH/NCATS Grant UL1TR000127
6 · The paper itself

Abstract

purposeExercise training is recommended for all patients with metabolic dysfunction-associated steatotic liver disease. Whether exercise training improves liver histology independent of body weight loss remains controversial. Given the increasing reliance on non-invasive biomarkers as a surrogate for liver histology, we investigated the relationship between exercise training and improvement in liver histology using the MASH Resolution Index (MASH-RI), a validated composite score of multiple biomarkers, in a post hoc analysis of the NASHFit trial.

methodsThis study randomized adults with biopsy-proven MASH to moderate-intensity aerobic exercise training or standard of care for 20 weeks. Mediterranean-informed dietary counseling was provided to each group. Change in the MASH-RI was measured and compared between the two groups (n = 23).

resultsApplying the MASH-RI, those who performed exercise training achieved MASH resolution nearly three times more often (33% vs. 13%, p < 0.01) versus those who received standard of care. Exercise training improved individual biomarkers included in the MASH-RI, including ALT, AST, and MRI-PDFF.

conclusionExercise training leads to MASH resolution, as defined by the MASH-RI at greater rates than standard lifestyle counseling. Future research is needed to determine how best to use the MASH-RI as a therapeutic monitoring tool to gauge response to lifestyle intervention. CLINICAL

trial registrationNCT03518294.

Indexed as

Aerobic exerciseMASH Resolution IndexMetabolic dysfunction-associated steatohepatitisMetabolic dysfunction-associated steatotic liver disease

Identifiers

PMID40900364
PMCPMC12946340

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.