Evidence map›Paper›PMID 40900334›Full record

ArticleExperimental brain research2025

Neural correlates of forward and backward walking in MS: insights from myelin water imaging.

Patrick G Monaghan, Taylor N Takla, Maryam M Abbawi, Michael VanNostrand, Ana M Daugherty, Jeffrey A Stanley, Nora E Fritz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental brain research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Patrick G MonaghanDepartment of Health Care Sciences, Wayne State University, Eugene Applebaum College of Pharmacy and Health Care Sciences, 259 Mack Avenue, Detroit, MI, USA. patrick.monaghan@wayne.edu.
Taylor N TaklaTranslational Neuroscience Program, Wayne State University, Detroit, MI, USA.
Maryam M AbbawiDepartment of Health Care Sciences, Wayne State University, Eugene Applebaum College of Pharmacy and Health Care Sciences, 259 Mack Avenue, Detroit, MI, USA.
Michael VanNostrandDepartment of Health Care Sciences, Wayne State University, Eugene Applebaum College of Pharmacy and Health Care Sciences, 259 Mack Avenue, Detroit, MI, USA.
Ana M DaughertyTranslational Neuroscience Program, Wayne State University, Detroit, MI, USA.
Jeffrey A StanleyTranslational Neuroscience Program, Wayne State University, Detroit, MI, USA.
Nora E FritzDepartment of Health Care Sciences, Wayne State University, Eugene Applebaum College of Pharmacy and Health Care Sciences, 259 Mack Avenue, Detroit, MI, USA.

Funding

Backward Walking as a Novel Fall Prediction Tool for Multiple SclerosisR21HD106133 · NICHD · WAYNE STATE UNIVERSITY · PI FRITZ, NORA E. · 2022 to 2023
$412k
Investigating Fear of Falling in Multiple Sclerosis: An Interplay of Neural, Motor, Cognitive, and Psychological FactorsF31HD116491 · NICHD · WAYNE STATE UNIVERSITY · PI TAKLA, TAYLOR · 2024 to 2025
$97k
National Multiple Sclerosis Society MB-2107-38295NICHD NIH HHS F31 HD116491NICHD NIH HHS R21 HD106133NIH HHS F31HD116491NIH HHS R21HD106133
6 · The paper itself

Abstract

Mobility impairments and increased fall risk are common in multiple sclerosis (MS), resulting from myelin degradation in motor pathways. While forward walking is a common mobility assessment, backward walking shows greater sensitivity in distinguishing fallers due to its increased postural and cognitive demands. However, the neurobiological mechanisms underlying backward walking deficits remain unclear. This study examined associations among myelin water imaging (MWI) metrics-myelin water fraction (MWF) and geometric mean of intermediate-T2 relaxation times (geomT

Indexed as

Multiple Sclerosis, Relapsing-RemittingMyelin SheathWalkingAdultCerebellumCorpus CallosumFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPyramidal TractsBackward walkingMultiple sclerosisMyelin water imagingStructure-function relation

Identifiers

PMID40900334
PMCPMC13000747

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.