Evidence map›Paper›PMID 40900326›Full record

SynthesisEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2026

A systematic review on oncological outcomes, functional results, and laryngeal preservation in vertical partial laryngectomies vs. transoral laser microsurgery for early stage glottic cancer.

Sara Bassani, Rogerio Aparecido Dedivitis, Gabriele Molteni, Erica Zampieri, Cecilia Dalmazzini, Mario Augusto Ferrari de Castro, Luiz Paulo Kowalski

Abstract readSystematic ReviewComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Definitive radiotherapy for early stage glottic cancer: a quarter-century of single-institution experience with long-term outcomes and late events.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Observational
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sara BassaniOtolaryngology-Head and Neck Surgery Department, University of Verona, Piazzale L.A. Scuro, 10, Verona, 37134, Italy. sarabassani1@gmail.com.ORCID http://orcid.org/0000-0002-3027-5967
Rogerio Aparecido DedivitisDepartment of Head and Neck Surgery, University of Sao Paulo School of Medicine, Sao Paulo, Brazil.
Gabriele MolteniDepartment of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.
Erica ZampieriOtolaryngology-Head and Neck Surgery Department, University of Verona, Piazzale L.A. Scuro, 10, Verona, 37134, Italy.
Cecilia DalmazziniDepartment of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.
Mario Augusto Ferrari de CastroDepartment of Head and Neck Surgery, University of Sao Paulo School of Medicine, Sao Paulo, Brazil.
Luiz Paulo KowalskiDepartment of Head and Neck Surgery, University of Sao Paulo School of Medicine, Sao Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo compare the oncological and functional outcomes of transorallaser microsurgery (TLM) and vertical partial laryngectomy (VPL) in earlystageglottic carcinoma (T1-T2).

methodsA systematic review following PRISMA guidelines analyzedcomparative studies from 2000 to 2024 in PubMed, EMBASE, and Web ofScience. Outcomes included local control, recurrence rates, larynxpreservation, survival, voice quality, and complications.

resultsEight studies met inclusion criteria. TLM and VPL showed comparablesurvival rates for T1 tumors, but VPL provided better local control and larynxpreservation in T2 and anterior commissure involvement cases. TLM had higherrecurrence risk but superior functional outcomes, including better voicepreservation, shorter hospital stays, and lower complication rates.

conclusionBoth techniques are viable, but TLM is preferred for T1 tumors,while VPL should be considered for T2 lesions because of higher local controlrates. Patient priorities and tumor characteristics should guide surgical choice.

Indexed as

GlottisLaryngeal NeoplasmsLaryngectomyLaser TherapyMicrosurgeryHumansNeoplasm Recurrence, LocalNeoplasm StagingTreatment OutcomeVoice QualityGlottic carcinomaLarynx preservationSurvivalSwallowingTransoral laser microsurgeryVertical partial laryngectomyVoice

Identifiers

PMID40900326
PMCPMC12987851

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.