Evidence map›Paper›PMID 40900249›Full record

ArticleCEN case reports2025

Light chain proximal tubulopathy in Sjögren syndrome: the critical role of tubular function tests in revealing a hidden threat.

Haruki Mae, Go Kanzaki, Yumeka Inamura, Nanae Matsuo, Shiko Honma, Kazuhito Suzuki, Nobuo Tsuboi, Kensuke Joh, Shingo Yano, Takashi Yokoo

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in CEN case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Haruki MaeDivision of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-Ku, Tokyo, 105-8461, Japan.ORCID 0009-0005-2472-1333
Go KanzakiDivision of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-Ku, Tokyo, 105-8461, Japan. g-kanzaki@jikei.ac.jp.
Yumeka InamuraDivision of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-Ku, Tokyo, 105-8461, Japan.
Nanae MatsuoDivision of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-Ku, Tokyo, 105-8461, Japan.
Shiko HonmaDivision of Pathology, Department of Internal Medicine, The Jikei University School of Medicine, Minato, Tokyo, Japan.
Kazuhito SuzukiDivision of Clinical Oncology and Hematology, Department of Internal Medicine, The Jikei University School of Medicine, Minato, Tokyo, Japan.
Nobuo TsuboiDivision of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-Ku, Tokyo, 105-8461, Japan.
Kensuke JohDivision of Pathology, Department of Internal Medicine, The Jikei University School of Medicine, Minato, Tokyo, Japan.
Shingo YanoDivision of Clinical Oncology and Hematology, Department of Internal Medicine, The Jikei University School of Medicine, Minato, Tokyo, Japan.
Takashi YokooDivision of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-Ku, Tokyo, 105-8461, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 65-year-old female patient with Sjögren syndrome (SJS) and tubulointerstitial nephritis (TIN) confirmed by kidney biopsy results 7 years previously presented to our department with progressive kidney function deterioration. Laboratory findings revealed increased serum creatinine level accompanied with deterioration of tubular function. Although she already had signs of proximal tubular dysfunction due to TIN from 7 years before, deterioration of the proximal tubule related parameters was particularly prominent. Owing to the substantial increase in the IgG level, monoclonal gammopathy was considered. Subsequent immunoelectrophoresis of the serum and urine revealed the presence of monoclonal IgG-κ. A repeat kidney biopsy revealed crystalline inclusions in the proximal tubules that tested positive for κ light chain. Along with findings from the bone marrow biopsy, this led to the diagnosis of light chain proximal tubulopathy (LCPT) secondary to multiple myeloma. Chemotherapy was initiated promptly which resulted in stabilization of renal function and improvement of tubular function. Vigilant monitoring of the tubular function is essential for patients with SJS. Deterioration of proximal tubule parameters, especially when accompanied by increased IgG levels, should prompt the investigation of monoclonal gammopathy and the consideration of kidney biopsy.

Indexed as

Kidney Tubules, ProximalMultiple MyelomaNephritis, InterstitialSjogren's SyndromeAgedBiopsyCreatinineFemaleHumansImmunoglobulin GImmunoglobulin kappa-ChainsImmunoglobulin Light ChainsKidneyKidney Function TestsParaproteinemiasCreatinineImmunoglobulin GImmunoglobulin kappa-ChainsImmunoglobulin Light ChainsLight chain proximal tubulopathyMonoclonal gammopathySjögren syndromeTubular dysfunctionTubulointerstitial nephritis

Identifiers

PMID40900249
PMCPMC12605943

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.