Evidence map›Paper›PMID 40900229›Full record

ReviewVirchows Archiv : an international journal of pathology2025

S100-positive stroma in salivary gland basal cell adenoma: recent progress and future perspectives.

Eiichi Sasaki, Katsuhiro Masago, Yasuko Fujita

Abstract readReview
PubMed Publisher
In one paragraph

Review in Virchows Archiv : an international journal of pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Eiichi SasakiDepartment of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya, 464-8681, Japan. sasakia1es@gmail.com.ORCID http://orcid.org/0000-0002-6385-8341
Katsuhiro MasagoDepartment of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya, 464-8681, Japan.
Yasuko FujitaDepartment of Pathology, Saga University Hospital, Saga, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Basal cell adenoma (BCA) with S100-positive stroma exhibits tricellular differentiation, consisting of bilayered epithelial cells and S100-positive spindle-shaped stromal cells. While the neoplastic nature of the stromal component has been supported by multiple lines of evidence, its myoepithelial origin, suggested by ultrastructural analysis, has not yet been confirmed by other methodological approaches. This mini-review summarizes the key findings of ultrastructural, immunohistochemical and molecular studies with a particular emphasis on the biological nature of the stromal component. Elucidating the lineage and molecular profile of this unique stroma may contribute to a more refined classification and enhance our understanding of salivary gland tumors.

Indexed as

AdenomaS100 ProteinsSalivary Gland NeoplasmsStromal CellsBiomarkers, TumorHumansImmunohistochemistryBiomarkers, TumorS100 ProteinsBasal cell adenomaBeta-cateninCTNNB1MicrodissectionMyoepithelium-derived stroma

Identifiers

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.