Evidence map›Paper›PMID 40900144›Full record

ArticleEmerging microbes & infections2025

Influenza A virus-induced interferon-alpha production by myeloid dendritic cells and macrophages requires productive infection.

Marc A Niles, Stefanie Kronhart, Katharina E Decker, Patricia Gogesch, Bevan Sawatsky, Svenja Stock, Georg Kochs, Zoe Waibler, Martina Anzaghe

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Emerging microbes & infections, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. International journal of biological sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Marc A NilesDivision of Immunology, Paul-Ehrlich-Institut, Langen, Germany.ORCID 0000-0002-5791-1644
Stefanie KronhartDivision of Immunology, Paul-Ehrlich-Institut, Langen, Germany.
Katharina E DeckerDivision of Immunology, Paul-Ehrlich-Institut, Langen, Germany.
Patricia GogeschDivision of Immunology, Paul-Ehrlich-Institut, Langen, Germany.
Bevan SawatskyDivision of Veterinary Medicine, Paul-Ehrlich-Institut, Langen, Germany.
Svenja StockSafety of Biomedicines and Diagnostics Division, Paul-Ehrlich-Institut, Langen, Germany.
Georg KochsInstitute of Virology, Medical Centre, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Zoe WaiblerDivision of Immunology, Paul-Ehrlich-Institut, Langen, Germany.ORCID 0000-0001-5758-2652
Martina AnzagheDivision of Immunology, Paul-Ehrlich-Institut, Langen, Germany.ORCID 0000-0002-7983-3835

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe Influenza A virus (IAV) infections are accompanied by a cytokine storm with type I interferon (IFN) as the main driver. Besides epithelial cells, alveolar macrophages and infiltrating dendritic cells are target cells for IAV. IAV are classified into different strains, defined by their major surface glycoproteins haemagglutinin (HA) and neuraminidase (NA). So far, 19 HA subtypes and 11 NA subtypes are known. However, it is not well understood, why infection with certain IAV strains results in a cytokine storm with severe outcomes, while other IAV strains only cause mild infections. In order to address this question, we investigated six seasonal and five highly pathogenic avian IAV (HPAIV) strains using primary human

Indexed as

Dendritic CellsInfluenza A virusInfluenza, HumanInterferon-alphaMacrophagesAnimalsHumansInterferon-alphacytokine stormdendritic cellsInfluenza A virusmacrophagesproductive infectiontype I interferon

Identifiers

PMID40900144
PMCPMC12444950

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.