ArticleJournal of surgical oncology2025
Effect of Surgical Margins on Local Recurrence Patterns of Myxofibrosarcomas: A Retrospective Cohort Study From the Stockholm Sarcoma Centre.
Article in Journal of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Optimising Clinical Outcomes Following R1 Resection in Soft Tissue Sarcoma: An Evidence-Based Approach.Current treatment options in oncology · 2026Review
- Navigating the Role of Radiotherapy for Extremity Soft Tissue Sarcomas.Biomedicines · 2026Review
- Staged Resection with Temporizing VAC and Local Recurrence for Soft Tissue Sarcomas: A Multi-Institutional Review.Cancers · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionOne of the most common subgroups of soft tissue sarcomas are myxofibrosarcomas (MFS), which possess an infiltrative and aggressive growth pattern with a tendency for local recurrence (LR). MFS presents significant management challenges due to difficulties in achieving satisfactory surgical margins. The present study describes the LR pattern of MFS and its association with resection margin, re-excision surgery and adjuvant radiotherapy.
methodThis is a registry study conducted at the Sarcoma Centre at Karolinska University Hospital, Stockholm. All patients who underwent surgery with curative aim for MFS in this centre between 2010 and 2023 were included.
resultsLR was documented in 17/87 patients. Surgical margin was predictive of LR but not overall patient survival. The cumulative LR incidence at 3.5 years for intralesional, marginal, and wide margins were 80%, 40% and 10% respectively. RT was not shown to confer any suppressive effect on LR. Amputation was needed in five patients for local disease control.
conclusionMargins are the foremost determinants of LR for MFS. Proactive surgical management should be considered when margins are marginal.
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