Evidence map›Paper›PMID 40899995›Full record

ArticleAntimicrobial agents and chemotherapy2025

Population pharmacokinetics and Monte Carlo-based dosing optimization of trimethoprim-sulfamethoxazole.

Bo Chen, Yiying Chen, Ming Chen, Yunyi Mao, Yingbin Huang, Lili Zhou, Wenwei Wu, Xueyong Li, Xuemei Wu, Yu Cheng and 1 more

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Bo Chen *Department of Pharmacy, Fujian Medical University Union Hospital, Fuzhou, China.ORCID 0009-0004-7085-4586
Yiying Chen *Department of Pharmacy, Fujian Medical University Union Hospital, Fuzhou, China.
Ming ChenDepartment of Pharmacy, Fujian Medical University Union Hospital, Fuzhou, China.
Yunyi MaoDepartment of Pharmacy, Fujian Medical University Union Hospital, Fuzhou, China.
Yingbin HuangDepartment of Pharmacy, Fujian Medical University Union Hospital, Fuzhou, China.
Lili ZhouDepartment of Critical Care Medicine, Fujian Medical University Union Hospital, , Fuzhou, China.
Wenwei WuDepartment of Critical Care Medicine, Fujian Medical University Union Hospital, , Fuzhou, China.
Xueyong LiDepartment of Pharmacy, Fujian Medical University Union Hospital, Fuzhou, China.ORCID 0000-0002-4064-3735
Xuemei WuDepartment of Pharmacy, Fujian Medical University Union Hospital, Fuzhou, China.
Yu ChengDepartment of Pharmacy, Fujian Medical University Union Hospital, Fuzhou, China.
Hongqiang QiuDepartment of Pharmacy, Fujian Medical University Union Hospital, Fuzhou, China.ORCID 0000-0003-3285-8768

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to develop population pharmacokinetic (PopPK) models for intravenous sulfamethoxazole (SMX) and trimethoprim (TMP) to optimize dosing regimens for the treatment of

Indexed as

Pneumonia, PneumocystisTrimethoprim, Sulfamethoxazole Drug CombinationAdultAgedArylamine N-AcetyltransferaseCytochrome P-450 CYP2C9FemaleHumansMaleMiddle AgedMonte Carlo MethodPneumocystis cariniiProspective StudiesArylamine N-AcetyltransferaseCYP2C9 protein, humanCytochrome P-450 CYP2C9NAT2 protein, humanTrimethoprim, Sulfamethoxazole Drug Combinationdose optimizationMonte Carlo simulationpopulation pharmacokineticsrenal dysfunctionsulfamethoxazoletrimethoprim

Identifiers

PMID40899995
PMCPMC12587597

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.