ArticleInternational journal of surgery (London, England)2026
Optimal surgical strategies in patients with T1 and T2 gallbladder cancer: necessity of lymph node dissection and liver resection: A retrospective cohort study.
Article in International journal of surgery (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Extended Lymphadenectomy is Associated with Better Survival Outcome in Resected T1b-T4 Gallbladder Cancer: A 505-Patient Cohort Study.Annals of surgical oncology · 2026Article
- Gallbladder large cell neuroendocrine carcinoma in a patient with multiple myeloma: a case report and literature review.Frontiers in oncology · 2025Article
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7 authors.
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Abstract
backgroundThe optimal surgical extent for T1 and T2 gallbladder (GB) cancer remains debated. This study aimed to evaluate the impact of lymph node (LN) dissection and liver resection on survival outcomes in T1 and T2 GB cancer.
methodsFrom 2010 to 2018, a retrospective analysis was conducted on 419 patients with pathologically confirmed T1 and T2 GB cancer who underwent curative surgery at a tertiary institution. Patients with other histologies, concurrent other organ resection, or incomplete data were excluded. LN dissection was defined as the removal of LNs ≥6. Survival outcomes were analyzed based on LN dissection and liver resection.
resultsThe cohort included 118 T1 and 241 T2 GB cancer patients. In T1 GB cancer, 5-year survival rate (5YSR) was similar between patients with and without LN dissection (87.0% vs. 86.6%, p = 0.208). Subgroup analyses of T1a and T1b showed no significant impact (p = 0.191 and p = 0.841). Multivariate analysis indicated that LN dissection was not associated with overall survival (hazard ratio 1.504, p = 0.534). In T2 GB cancer, 5YSR was similar between radical cholecystectomy and simple cholecystectomy with LN dissection (72.3% vs. 68.8%, p = 0.131). Subgroup analysis showed no significant difference in T2a (p = 0.180). Multivariate analysis confirmed simple cholecystectomy with LN dissection was comparable to radical cholecystectomy (hazard ratio 1.009, p = 0.983).
conclusionSimple cholecystectomy is adequate for T1 GB cancer, regardless of LN dissection. For T2 GB cancer, simple cholecystectomy with LN dissection can be performed without liver resection in selected patients, particularly in T2a, provided adequate LN dissection is achieved.
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