Evidence map›Paper›PMID 40899814›Full record

ArticleJournal of virology2025

An attenuated African swine fever virus with deletions of the

Guorui Peng, Xin Zhao, Xingqi Zou, He Zhang, Junjie Zhao, Xuezhi Zuo, Shuguang Tan, Ruizhi Wu, Xue Guan, Shihua Li and 8 more

Abstract read
In one paragraph

Article in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Guorui Peng *College of Veterinary Medicine, China Agricultural University, Beijing, China.ORCID 0009-0007-5513-1277
Xin Zhao *CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.ORCID 0000-0002-2001-1343
Xingqi Zou *China/WOAH Reference Laboratory for Classical Swine Fever, China Institute of Veterinary Drug Control, Beijing, China.
He ZhangCAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Junjie ZhaoChina/WOAH Reference Laboratory for Classical Swine Fever, China Institute of Veterinary Drug Control, Beijing, China.
Xuezhi ZuoCollege of Veterinary Medicine, China Agricultural University, Beijing, China.
Shuguang TanCAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Ruizhi WuCollege of Veterinary Medicine, China Agricultural University, Beijing, China.
Xue GuanChina/WOAH Reference Laboratory for Classical Swine Fever, China Institute of Veterinary Drug Control, Beijing, China.
Shihua LiCAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.ORCID 0000-0003-3608-4106
Yuan XuChina/WOAH Reference Laboratory for Classical Swine Fever, China Institute of Veterinary Drug Control, Beijing, China.
Yingju XiaChina/WOAH Reference Laboratory for Classical Swine Fever, China Institute of Veterinary Drug Control, Beijing, China.
Xiaoai XuChina/WOAH Reference Laboratory for Classical Swine Fever, China Institute of Veterinary Drug Control, Beijing, China.
Lu XuChina/WOAH Reference Laboratory for Classical Swine Fever, China Institute of Veterinary Drug Control, Beijing, China.
Yuanyuan ZhuChina/WOAH Reference Laboratory for Classical Swine Fever, China Institute of Veterinary Drug Control, Beijing, China.
Jinhua LiuCollege of Veterinary Medicine, China Agricultural University, Beijing, China.ORCID 0000-0002-4128-1043
Yebing LiuChina/WOAH Reference Laboratory for Classical Swine Fever, China Institute of Veterinary Drug Control, Beijing, China.ORCID 0009-0005-2715-6122
George Fu GaoCAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.ORCID 0000-0002-3869-615X

Funding

CAS Project for Young scientists in Basic Research YSBR-083National Key Research and Development Program of China 2021YFC2300200, 2023YFC2307801, 2021YFD1800105-1, 2025YFC2311800, 2024YFD1800502National Natural Science Foundation of China 32270157,82222040
6 · The paper itself

Abstract

African swine fever (ASF) has caused a devastating pandemic among domestic and wild swine, leading to significant economic losses in the global swine industry. Recombinant live-attenuated vaccines are a potential option for the control of ASF. However, safe and effective vaccines against the ASF virus (ASFV) are not yet commercially available, and thus, additional vaccine candidates still need to be developed. In this study, we demonstrate that the simultaneous deletion of the ASFV genes

Indexed as

African Swine FeverAfrican Swine Fever VirusViral ProteinsViral VaccinesAnimalsAntibodies, ViralGene DeletionSwineVaccines, AttenuatedVirulenceAntibodies, ViralVaccines, AttenuatedViral ProteinsViral VaccinesA137RAfrican swine fever virus (ASFV)attenuationCD2vdouble gene knockout strainprotection

Identifiers

PMID40899814
PMCPMC12456006

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.