ArticleAdvanced materials (Deerfield Beach, Fla.)2025
Peptide Coacervates with Metal-Phenolic Membranes Modulate Glucose Metabolism and Enhance Cancer Immunotherapy.
Article in Advanced materials (Deerfield Beach, Fla.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Organization from cell to tissue derived delivery systems for immunotherapy.Materials today. Bio · 2026Article
- Characterizing risk groups in papillary thyroid carcinoma through T-Cell mediated tumor cell killing-related genes: a pathway to therapeutic predictions.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Functionalized Coacervates for Cancer Therapy: Advances and Prospects in Phase-Separation-Based Intelligent Drug Delivery.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Metal-phenolic networks: a promising strategy for cancer immunotherapy.Journal of translational medicine · 2026Review
- Photothermal Performance of Metal-Phenolic Networks and Its pH-Dependent Coordination Regulation.Molecules (Basel, Switzerland) · 2026Article
- Peptide Coacervates with Metal-Phenolic Membranes Modulate Glucose Metabolism and Enhance Cancer Immunotherapy.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Integrin alpha L: structure, cellular functions, and emerging role in human diseases.Frontiers in immunology · 2025Review
Corrections and comments
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Authors and funding
18 authors.
Funding
Abstract
Glucose consumption by tumors induces metabolic restriction of T cells, which results in immune evasion and tumor progression. Regulating cellular metabolism represents a promising strategy to enhance cancer immunotherapy; however, redirecting glucose utilization from tumor cells to T cells is challenging. Herein, the activation of cytotoxic T cells using engineered peptide coacervates (PCs) containing interferon alpha (IFNα) and membranized with metal-phenolic networks (MPNs) (PC-IFNα@MPNs), which promote glucose uptake and glycolysis, is reported. PC-IFNα@MPNs modulate the molecular conformation of the co-stimulatory lymphocyte function-associated antigen 1 on CD8
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.