Evidence map›Paper›PMID 40899507›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2025

Implantable Light-Powered Human Designer Cells for Electrical Energy Generation.

Shuai Xue, Zhihua Lin, Debasis Maity, Preetam Guha Ray, Mingqi Xie, Martin Fussenegger

Abstract read
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shuai XueDepartment of Biosystems Science and Engineering, ETH Zürich, Klingelbergstrasse 48, Basel, CH-4056, Switzerland.
Zhihua LinDepartment of Biosystems Science and Engineering, ETH Zürich, Klingelbergstrasse 48, Basel, CH-4056, Switzerland.
Debasis MaityDepartment of Biosystems Science and Engineering, ETH Zürich, Klingelbergstrasse 48, Basel, CH-4056, Switzerland.
Preetam Guha RayDepartment of Biosystems Science and Engineering, ETH Zürich, Klingelbergstrasse 48, Basel, CH-4056, Switzerland.
Mingqi XieWestlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, 310024, China.
Martin FusseneggerDepartment of Biosystems Science and Engineering, ETH Zürich, Klingelbergstrasse 48, Basel, CH-4056, Switzerland.ORCID 0000-0001-8545-667X

Funding

European Research Council 785800HORIZON EUROPE European Research Council ElectroGene 785800Ministry of Science and Technology 2020YFA0909200Natural Science Foundation of China 32071429Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung NCCR Molecular Systems Engineering
6 · The paper itself

Abstract

Herein, an implantable, miniature biohybrid device has been developed that utilizes light-dependent ion-gradient formation by genetically engineered human designer cells, expressing light-activated ion channels and proton pumps to generate electrical potential and deliver electrical energy. These designer cells are cultured in custom-designed polycarbonate chambers, connected by electrodes and separated from an ion reservoir by a proton-selective Nafion membrane. Upon illumination, the light-activated channels and pumps on the designer cells establish a sustained proton gradient across the Nafion membrane, which drives an electrical current in the external circuit. When exposed to simulated ambient sunlight of 3 mW cm

Indexed as

Bioelectric Energy SourcesLightProstheses and ImplantsAnimalsFluorocarbon PolymersHEK293 CellsHumansMiceOptogeneticsSolar EnergyFluorocarbon Polymerselectrogeneticsgenetic engineeringlight‐sensitive membrane proteinsphotovoltagesolar cellssynthetic biology

Identifiers

PMID40899507
PMCPMC12617042

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.