Evidence map›Paper›PMID 40899493›Full record

ArticleAngewandte Chemie (International ed. in English)2025

Selective Chemical Manipulation of Mannosyl- and Galactosyl-Queuosine in tRNAs of Living Cells.

Alexander Pichler, Elsa Peev, Qingyi Ge, Ghofrane Ben Helal, Matthias Heiss, Stylianos Xefteris, Markus Müller, Thomas Carell

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alexander Pichler *Center for Nucleic Acid Therapeutics at the Department of Chemistry, Institute for Chemical Epigenetics, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377, München, Germany.ORCID 0000-0002-9842-0155
Elsa Peev *Center for Nucleic Acid Therapeutics at the Department of Chemistry, Institute for Chemical Epigenetics, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377, München, Germany.
Qingyi GeCenter for Nucleic Acid Therapeutics at the Department of Chemistry, Institute for Chemical Epigenetics, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377, München, Germany.ORCID 0009-0003-7922-6749
Ghofrane Ben HelalCenter for Nucleic Acid Therapeutics at the Department of Chemistry, Institute for Chemical Epigenetics, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377, München, Germany.
Matthias HeissCenter for Nucleic Acid Therapeutics at the Department of Chemistry, Institute for Chemical Epigenetics, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377, München, Germany.ORCID 0000-0002-6770-9511
Stylianos XefterisCenter for Nucleic Acid Therapeutics at the Department of Chemistry, Institute for Chemical Epigenetics, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377, München, Germany.ORCID 0009-0002-9008-3243
Markus MüllerCenter for Nucleic Acid Therapeutics at the Department of Chemistry, Institute for Chemical Epigenetics, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377, München, Germany.ORCID 0000-0002-3579-3317
Thomas CarellCenter for Nucleic Acid Therapeutics at the Department of Chemistry, Institute for Chemical Epigenetics, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377, München, Germany.ORCID 0000-0001-7898-2831

Funding

BMBF Cluster4Future program (Cluster for Nucleic Acid Therapeutics Munich, CNATM 03ZU1201AACRC 1309 325871075CRC 1361 393547839European Research Council 741912Marie Sklodowska-Curie 861381RNAmed (Elite network of Bavaria)TRR 237 369799452
6 · The paper itself

Abstract

Queuosine is a hypermodified nucleoside found in the anticodon loop of tRNAs decoding the amino acids His, Asn, Tyr, and Asp. In tRNA

Indexed as

GalactoseMannoseNucleoside QRNA, TransferHumansGalactoseMannoseNucleoside QRNA, TransferEpitranscriptomicsGalactosylationMannosylationQueuineQueuosine

Identifiers

PMID40899493
PMCPMC12518689

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.