Evidence map›Paper›PMID 40899374›Full record

ReviewCancer medicine2025

Risk Assessment and Fertility Counseling for Hereditary Gynecological Cancer Syndromes.

Mei Zhao, Xiao-Ming Teng, Qiang Yan, Fan Hao

Abstract readReview
In one paragraph

Review in Cancer medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mei ZhaoReproductive Medical Center, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, P.R. China.
Xiao-Ming TengReproductive Medical Center, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, P.R. China.
Qiang YanReproductive Medical Center, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, P.R. China.
Fan HaoReproductive Medical Center, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, P.R. China.ORCID https://orcid.org/0000-0003-3479-8295

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo review the genetic basis, clinical characteristics, and management strategies of hereditary gynecologic cancers associated with hereditary cancer syndromes.

methodsLiterature on germline mutations, inheritance patterns, clinical manifestations, and fertility preservation strategies was reviewed.

resultsGermline pathogenic mutations, predominantly inherited in an autosomal dominant manner, increase susceptibility to gynecologic tumors with varying risks. Genomic sequencing has facilitated identification of high-risk individuals, underscoring the importance of tailored prevention, early detection, and treatment. Standardized counseling supports risk assessment, fertility preservation, and the formulation of individualized management strategies.

conclusionComprehensive genetic counseling and precision-based approaches are essential for effective prevention, diagnosis, and treatment of hereditary gynecologic cancers, while also addressing fertility preservation in affected patients.

Indexed as

Fertility PreservationGenetic CounselingGenital Neoplasms, FemaleNeoplastic Syndromes, HereditaryFemaleGenetic Predisposition to DiseaseGenetic TestingGerm-Line MutationHumansRisk Assessmentautosomal dominant inheritancecervical cancerendometrial cancerfertility preservationgenetic counselinghereditary gynecological cancersovarian cancer

Identifiers

PMID40899374
PMCPMC12405969

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.