Evidence map›Paper›PMID 40899250›Full record

ArticleBiochemistry2025

18-Crown-6-ether Utilizes Distinct Allosteric Interactions to Uncouple Transport by the Multidrug Efflux Pump EmrE.

Merissa Brousseau, Tapasyatanu Dash, Michael J Rourke, Vilius Kurauskas, Marco Tonelli, Kylie M Hibbs, Andrew R Buller, Michael T Marty, Katherine A Henzler-Wildman

Abstract read
In one paragraph

Article in Biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Protonated Structure of EmrE Reveals C-terminal Tail Gating Mechanism.bioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Merissa BrousseauBiochemistry Department, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.ORCID 0000-0003-0555-7177
Tapasyatanu DashChemistry Department, University of Texas at Austin, Austin, Texas 78712, United States.
Michael J RourkeChemistry Department, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.
Vilius KurauskasBiochemistry Department, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.
Marco TonelliBiochemistry Department, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.
Kylie M HibbsBiochemistry Department, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.
Andrew R BullerChemistry Department, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.ORCID 0000-0002-9635-4844
Michael T MartyChemistry Department, University of Texas at Austin, Austin, Texas 78712, United States.ORCID 0000-0001-8115-1772
Katherine A Henzler-WildmanBiochemistry Department, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.ORCID 0000-0002-5295-2121

Funding

Chemistry-Biology Interface Training ProgramT32GM008505 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BLACKWELL, HELEN E. · 1993 to 2023
$9.8M
NMR User Program at NMRFAMR24GM141526 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Katherine Anne Henzler-Wildman · 2021 to 2026
$6.4M
Unravelling Membrane Protein-Lipid Interactions using Nanodiscs and Mass SpectrometryR35GM128624 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI Michael T Marty · 2018 to 2026
$3.6M
Molecular Mechanisms of Channels and TransportersR35GM141748 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Katherine Anne Henzler-Wildman · 2021 to 2026
$2.7M
Chemistry-Biology Interface Training ProgramT32GM152341 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Helen E. Blackwell · 2024 to 2026
$1.6M
Engineering promiscuous enzymes for synthesis of biological building blocksR35GM153276 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BULLER, ANDREW · 2024 to 2025
$800k
NIGMS NIH HHS R24 GM141526NIGMS NIH HHS R35 GM128624NIGMS NIH HHS R35 GM141748NIGMS NIH HHS R35 GM153276NIGMS NIH HHS T32 GM008505NIGMS NIH HHS T32 GM152341
6 · The paper itself

Abstract

The recent discovery that the model multidrug efflux pump from

Indexed as

AntiportersCrown EthersEscherichia coliEscherichia coli ProteinsAllosteric RegulationBiological Transport18-crown-6AntiportersCrown EthersEmrE protein, E coliEscherichia coli Proteins

Identifiers

PMID40899250
PMCPMC12440375

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.