Evidence map›Paper›PMID 40899193›Full record

ArticleNeurourology and urodynamics2025

Quantitative Mechanics of the Bladder During Voiding Using MRI.

Juan Pablo Gonzalez-Pereira, Wade Bushman, Alejandro Roldan-Alzate

Abstract read
In one paragraph

Article in Neurourology and urodynamics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Juan Pablo Gonzalez-PereiraDepartment of Mechanical Engineering, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID https://orcid.org/0000-0002-3580-3570
Wade BushmanDepartment of Urology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Alejandro Roldan-AlzateDepartment of Mechanical Engineering, Radiology, Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Funding

Coordinating and Bioinformatics Unit for the MMPC/DiaCompU24DK076169 · NIDDK · AUGUSTA UNIVERSITY · PI MCINDOE, RICHARD A. · 2006 to 2018
$42.4M
MR imaging-based Quantitative Analysis of Bladder Anatomy and Function in BPH/LUTSR01DK126850 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI ROLDAN, ALEJANDRO · 2021 to 2023
$680k
NIDDK NIH HHS R01 DK126850NIDDK NIH HHS U24 DK076169This study was supported by the National Institute of Diabetes and Digestive and Kidney Diseases: R01 DK126850-01 and Diacomp DK-076169.
6 · The paper itself

Abstract

purposeUro-Dynamic MRI was used to non-invasively quantify bladder biomechanics, characterizing the fundamental relationship between bladder wall surface area and bladder volume during voiding.

methodsDifferential Subsampling with Cartesian Ordering MRI sequence was used to acquire multiple volumetric bladder images during the voiding in five normal male subjects. Images were imported into MIMICS. Bladder volume and bladder wall surface area were obtained using threshold-based image segmentation and the main axes of bladder wall deformation were measured/tracked throughout voiding. Linear anatomical measurements yielded bladder volume estimation using a generalized ellipsoid approximation and facilitated direct comparison with the metrics obtained from the 3D renderings.

resultsEllipsoid volume approximation showed high agreement with volume from 3D renderings; however, this agreement does not hold for flow rates derived from both approaches. Analysis of changes in volume and surface area from 3D renderings show bladder deformation that varies throughout voiding, behaving closer to an idealized spherical bladder past the point of maximum flow. Further analysis suggests an asymmetrical and nonconstant change of bladder dimensions in relation to changes in bladder volume, and a generalized concentric contraction of the bladder wall past maximum flow during the voiding event.

conclusionUro-Dynamic MRI allowed time-resolved analysis of the relationship between changes in anatomy-based measurements, volume and surface area of the bladder. This methodology highlights the use of Uro-Dynamic MRI as a powerful tool to comprehensively extract anatomical information of the bladder and correlate this information with novel Noninvasive metrics to evaluate patient specific biomechanics. CLINICAL

trial registrationThe patients recruited for this study and data collected for this manuscript are not part of a clinical trial.

Indexed as

Magnetic Resonance ImagingUrinary BladderUrinationUrodynamicsAdultBiomechanical PhenomenaHealthy VolunteersHumansImaging, Three-DimensionalMaleasymmetricbladdercontractionmechanicsMRIvoiding

Identifiers

PMID40899193
PMCPMC12846870

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.