Evidence map›Paper›PMID 40899100›Full record

ArticleEuropean journal of immunology2025

Baseline Single-Cell Differences in Polyfunctionality Between Systemic Autoinflammatory Diseases Patients and Healthy Controls.

Aline Linder, Farah Diab, Loïc de Pontual, Irina Giurgea, Klaus Eyer

Abstract read
In one paragraph

Article in European journal of immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Aline LinderLaboratory For Functional Immune Repertoire Analysis, Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Switzerland.ORCID 0009-0008-0965-1949
Farah DiabSorbonne Université, Inserm, Maladies génétiques d'expression pédiatrique, Paris, France.
Loïc de PontualService de Pédiatrie, Hôpital Jean Verdier, Bondy, France.
Irina GiurgeaSorbonne Université, Inserm, Maladies génétiques d'expression pédiatrique, Paris, France.
Klaus EyerLaboratory For Functional Immune Repertoire Analysis, Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Switzerland.ORCID 0000-0001-9344-5110

Funding

Personalized Health and Related Technologies (PHRT) 2021-349
6 · The paper itself

Abstract

Dysregulated cytokine secretion and signaling underlie systemic autoinflammatory diseases (SAIDs). Here, we characterized immune dysregulation in SAID patients by profiling cytokine secretion at the single-cell level, establishing measurements for secretion dynamics and cellular polyfunctionality, compared with healthy controls, revealing natural variability within immune responses between donors.

Indexed as

Autoimmune DiseasesCytokinesInflammationAdultCase-Control StudiesFemaleHumansMaleMiddle AgedSingle-Cell AnalysisCytokines

Identifiers

PMID40899100
PMCPMC12405973

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.