Evidence map›Paper›PMID 40899093›Full record

ArticleEuropean journal of immunology2025

Perturbances in Both Circulating B and CD4

Laurens Bogers, Jasper Rip, Suzanne C Franken, Kirsten L Kuiper, Ana M Marques, Annet F Wierenga-Wolf, Marie-José Melief, Cato E A Corsten, Romy A M Klein Kranenbarg, Janet de Beukelaar and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Perturbances in Both Circulating B and CD4European journal of immunology · 2025
    Article
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Laurens BogersDepartment of Immunology, MS Center ErasMS, Erasmus University Medical Center, Rotterdam, The Netherlands.ORCID 0000-0002-8490-3076
Jasper RipDepartment of Immunology, MS Center ErasMS, Erasmus University Medical Center, Rotterdam, The Netherlands.ORCID 0000-0001-5780-9271
Suzanne C FrankenDepartment of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Kirsten L KuiperDepartment of Immunology, MS Center ErasMS, Erasmus University Medical Center, Rotterdam, The Netherlands.
Ana M MarquesDepartment of Immunology, MS Center ErasMS, Erasmus University Medical Center, Rotterdam, The Netherlands.
Annet F Wierenga-WolfDepartment of Immunology, MS Center ErasMS, Erasmus University Medical Center, Rotterdam, The Netherlands.
Marie-José MeliefDepartment of Immunology, MS Center ErasMS, Erasmus University Medical Center, Rotterdam, The Netherlands.
Cato E A CorstenDepartment of Neurology, MS Center ErasMS, Erasmus University Medical Center, Rotterdam, The Netherlands.
Romy A M Klein KranenbargDepartment of Neurology, MS Center ErasMS, Erasmus University Medical Center, Rotterdam, The Netherlands.
Janet de BeukelaarDepartment of Neurology, Albert Schweitzer Hospital, Dordrecht, The Netherlands.
Ide SmetsDepartment of Neurology, MS Center ErasMS, Erasmus University Medical Center, Rotterdam, The Netherlands.
Beatrijs H WokkeDepartment of Neurology, MS Center ErasMS, Erasmus University Medical Center, Rotterdam, The Netherlands.
Maarten J TitulaerDepartment of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Joost SmoldersDepartment of Immunology, MS Center ErasMS, Erasmus University Medical Center, Rotterdam, The Netherlands.ORCID 0000-0001-9766-8661
Marvin M van LuijnDepartment of Immunology, MS Center ErasMS, Erasmus University Medical Center, Rotterdam, The Netherlands.ORCID 0000-0002-1283-1018

Funding

Erasmus MC FoundationStichting de MerelStichting Dioraphte 2001 0403Stichting MS Research 19-1057 MSStichting MS Research 20-490f MS
6 · The paper itself

Abstract

Using spectral flow cytometry, we analyzed circulating lymphocyte subsets in treatment-naive individuals with multiple sclerosis (MS) and other central nervous system autoimmune diseases (CNS AIDs). Elevated B-cell and CD4

Indexed as

Autoimmune DiseasesAutoimmune Diseases of the Nervous SystemB-LymphocytesCD4-Positive T-LymphocytesMultiple SclerosisAdultFemaleFlow CytometryHumansMaleMiddle AgedReceptors, CXCR3Receptors, CXCR3anti‐AQP4 NMOSDautoimmune encephalitisdisease progressiondisease specificityMOGAD

Identifiers

PMID40899093
PMCPMC12405970

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.