Evidence map›Paper›PMID 40899090›Full record

ArticleClinical oral implants research2025

Dental Implants in Medically Compromised Patients Undergoing or After Receiving Anti-Resorptive or Radiotherapy: Retrospective Clinical and Radiographic Data.

Christian Mertens, Fabian Staudinger, Maximilian Smielowski, Thomas Rückschloss, Gregor Schnug, Jürgen Hoffmann, Oliver Ristow

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Article in Clinical oral implants research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Christian MertensDepartment of Oral- and Cranio-Maxillofacial Surgery, Heidelberg University Hospital, Heidelberg, Germany.ORCID 0000-0002-6305-364X
Fabian StaudingerDepartment of Oral- and Cranio-Maxillofacial Surgery, Heidelberg University Hospital, Heidelberg, Germany.ORCID 0009-0000-6307-809X
Maximilian SmielowskiDepartment of Oral- and Cranio-Maxillofacial Surgery, Heidelberg University Hospital, Heidelberg, Germany.
Thomas RückschlossDepartment of Oral- and Cranio-Maxillofacial Surgery, Heidelberg University Hospital, Heidelberg, Germany.
Gregor SchnugDepartment of Oral- and Cranio-Maxillofacial Surgery, Heidelberg University Hospital, Heidelberg, Germany.
Jürgen HoffmannDepartment of Oral- and Cranio-Maxillofacial Surgery, Heidelberg University Hospital, Heidelberg, Germany.
Oliver RistowDepartment of Oral- and Cranio-Maxillofacial Surgery, Heidelberg University Hospital, Heidelberg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

OBJECTIVE AND

aimA retrospective study to evaluate the clinical and radiological outcomes of dental implants placed in compromised patients who have undergone antiresorptive therapy (AR) or head and neck radiotherapy (IR). MATERIAL AND

methodsDental implant placement was evaluated in compromised patients undergoing or after receiving AR/IR therapy following specific preventive measures: antibiotic prophylaxis (2 days before and 5 days after surgery) and primary wound closure with submerged healing for 4 months. The primary outcome was implant survival during the observation period. Secondary outcomes included marginal bone loss, occurrence of osteonecrosis, and factors influencing implant survival.

resultsA total of 92 patients (59 IR, 32 AR) with 369 dental implants were included in the study. During a mean follow-up period of 25 months (SD: 16), 23 implants were lost (IR: 21, AR: 2). Implant survival rates were 92% and 98% for IR and AR, respectively. Identified risk factors for implant failure included placement in neomandibular/-maxillary sites, maxillary implantation, implant diameter < 4.2 mm, active smoking, and diabetes mellitus. The mean marginal bone loss was 0.57 mm (SD: 1.51) in the IR group and -0.09 mm (SD: 1.17) in the AR group.

conclusionWith comprehensive risk assessment and careful evaluation of implant indications, dental implants can serve as an effective dental rehabilitation option for patients undergoing or after receiving AR/IR therapy, provided strict adherence to preventive measures is maintained. Implants placed following AR therapy demonstrate higher survival rates and reduced marginal bone loss compared to those placed after IR therapy.

Indexed as

Bone Density Conservation AgentsDental Implantation, EndosseousDental ImplantsHead and Neck NeoplasmsAdultAgedAged, 80 and overAlveolar Bone LossDental Restoration FailureFemaleHumansMaleMiddle AgedRetrospective StudiesRisk FactorsTreatment OutcomeBone Density Conservation AgentsDental Implantsdental implantsdiphosphonatesfollow‐up studiesradiotherapyrisk assessmentrisk factorssurvival rate

Identifiers

PMID40899090
PMCPMC12669423

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